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Keywords: protein aggregation
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Articles
Essays Biochem (2023) 67 (2): 243–253.
Published: 29 March 2023
...Tara L. Pukala Protein aggregation is now recognized as a generic and significant component of the protein energy landscape. Occurring through a complex and dynamic pathway of structural interconversion, the assembly of misfolded proteins to form soluble oligomers and insoluble aggregates remains...
Articles
Essays Biochem (2022) 66 (7): 977–986.
Published: 16 December 2022
... Attribution License 4.0 (CC BY-NC-ND) . alpha synuclein amyloid copper metal binding Parkinsons disease protein aggregation Parkinson’s disease (PD), for which there is only symptomatic treatment [ 1 , 2 ], is the second most common neurodegenerative disorder after Alzheimer’s disease...
Articles
Essays Biochem (2022) 66 (7): 959–975.
Published: 16 December 2022
... 08 08 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 accelerator amyloid energy landscape inhibitor protein aggregation small-molecule modulator Amyloidosis is a class of protein-misfolding diseases characterised...
Articles
Essays Biochem (2022) 66 (7): 987–1000.
Published: 16 December 2022
... into protein aggregates, which have been widely implicated in Parkinson’s disease (PD) pathogenesis and other synucleinopathies. The self-assembly of α-Syn involves the structural conversion of soluble monomeric protein into oligomeric intermediates and eventually fibrillar aggregates of amyloids with cross-β...
Articles
Essays Biochem (2022) 66 (7): 891–900.
Published: 16 December 2022
... ]. fluorescence resonance energy transfer phase separation protein aggregation protein conformation protein dynamics single molecule Eukaryotes contain distinct subcompartments that facilitate the spatiotemporal regulation of numerous biochemical reactions [ 1 ]. Organelles are usually delineated...
Articles
Essays Biochem (2016) 60 (2): 173–180.
Published: 15 October 2016
... of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . amyloid autophagy chaperone-mediated autophagy immunoglobulin light chain lysosome macroautophagy mTOR Parkinson's disease protein aggregation protein misfolding proteostasis rapamycin TFEB α...
Articles
Essays Biochem (2016) 60 (2): 143–151.
Published: 15 October 2016
... phenotypes and are closely linked with the accumulation of microscopically visible deposits of aggregated proteins. These include inclusion bodies found in AD (Alzheimer's disease), HD (Huntington's disease) and ALS (amyotrophic lateral sclerosis) patient neurons. Protein aggregation is intimately linked...
Articles
Essays Biochem (2016) 60 (2): 163–172.
Published: 15 October 2016
... 2016 © 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2016 α-crystallin Hsp27 molecular chaperones protein aggregation protein folding regulation of apoptosis regulation of sHsps structure of sHsps substrate binding We...
Articles
Essays Biochem (2016) 60 (2): 181–190.
Published: 15 October 2016
... in affected cells and tissues. In this article, we recap amyloid aggregation pathways, describe prion-like propagation, elaborate on detrimental interactions of protein aggregates with the cellular protein quality control system and discuss why some aggregates are toxic, whereas others seem to be beneficial...
Articles
Essays Biochem (2014) 56: 53–68.
Published: 18 August 2014
... to remove organelles and other large particles in a controlled manner [ 18 ]. chaperone heat-shock protein Hsc70 (heat-shock cognate 70) Hsp90 (heat-shock protein 90) protein aggregation protein folding proteostasis The native state of functional proteins is a delicate, flexible...
Articles
Essays Biochem (2014) 56: 167–180.
Published: 18 August 2014
... ]. Further studies are necessary to elucidate the critical steps in the HTTex1 polymerization cascade. Neurodegenerative disorders caused by CAG repeat expansions share two main characteristics: the deposition of protein aggregates and neuronal cell death. However, the identification of a defined...
Articles
Articles
Essays Biochem (2013) 55: 119–131.
Published: 27 September 2013
... are associated with increased cellular stress and assault including DNA damage, reduced energy availability, protein aggregation and accumulation of damaged organelles. A reduction in autophagy activity has been observed in a number of ageing models and its up-regulation via pharmacological and genetic methods...