... proteasomal degradation by causing protein polyubiquitination. These have been used to degrade a range of disease-relevant proteins in cells, and some show promising efficacy in preclinical animal models, although their clinical efficacy and tolerability is yet to be proven. This review introduces current...

... on behalf of the Biochemical Society 2016 cellular targeting proteasomes protein misfolding ribosomes In all living systems, ribosomes synthesize proteins by assembling amino acids in a stepwise manner from the N-terminus towards the C-terminus. During synthesis, the growing polypeptide...