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Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 987–1000.
Published: 16 December 2022
... into protein aggregates, which have been widely implicated in Parkinson’s disease (PD) pathogenesis and other synucleinopathies. The self-assembly of α-Syn involves the structural conversion of soluble monomeric protein into oligomeric intermediates and eventually fibrillar aggregates of amyloids with cross-β...