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Keywords: neurodegeneration
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Articles
Essays Biochem (2023) 67 (1): 1–2.
Published: 03 March 2023
... 14 02 2023 17 02 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 astrocytes immunometabolism metabolism neural circuits neurodegeneration neurons Astrocytes are morphologically and functionally flexible cells...
Articles
Essays Biochem (2021) 65 (7): 1013–1024.
Published: 22 December 2021
... ABC transport proteins Alzheimers disease lipids neurodegeneration ATP-binding cassette (ABC) transporters are amongst the largest protein superfamily groups with 48 proteins classified into seven subfamilies, ABCA, ABCB, ABCC, ABCD, ABCE, ABCF and ABCG. ABC transporters are generally...
Articles
Essays Biochem (2021) 65 (7): 847–857.
Published: 22 December 2021
... enhance tau-aggregate toxicity, and discuss recent findings that implicate microglial phagocytosis of live neurons with tau aggregates as a mechanism of death. cell death neurodegeneration tau Correspondence: Aviva M. Tolkovsky ( amt1004@cam.ac.uk ) or Maria Grazia Spillantini ( mgs11...
Articles
Essays Biochem (2021) 65 (7): 941–948.
Published: 22 December 2021
...Patrick A. Lewis Cellular control of vesicle biology and trafficking is critical for cell viability, with disruption of these pathways within the cells of the central nervous system resulting in neurodegeneration and disease. The past two decades have provided important insights into both...
Articles
Essays Biochem (2021) 65 (7): 999–1011.
Published: 22 December 2021
... BY) . apoptosis enzyme activity genetics membrane dynamics neurodegeneration neurotrophic factors Membrane lipid rafts (MLRs) are specialised plasma membrane microdomains that are integral to the regulation of intracellular trafficking and signal transduction. MLRs contain high concentrations of four...
Articles
Essays Biochem (2020) 64 (5): 847–861.
Published: 20 October 2020
... dementia Genome instability Neurodegeneration Repeat expansion Amyotrophic lateral sclerosis (ALS) is a lethal degenerative motor neuron disease with a median survival of 2–4 years after diagnosis [ 1 ] and no available effective treatment [ 2 ]. Caused by loss of motor neurons in the motor cortex...
Articles
Essays Biochem (2018) 62 (5): 619–642.
Published: 03 December 2018
... disorders molecular basis of health and disease microbiology neurodegeneration Diabetes mellitus is a condition in which the body is unable to control blood glucose levels adequately, resulting in high blood glucose levels (hyperglycaemia). Symptoms include frequent urination due...
Articles
Essays Biochem (2014) 56: 111–123.
Published: 18 August 2014
...@mails.tjmu.edu.cn ). © The Authors Journal compilation © 2014 Biochemical Society 2014 Alzheimer's disease hyperphosphorylation neurodegeneration tau tauopathies As a major microtubule-associated protein, most tau-related studies have been focused on its functions within the cytoskeleton...
Articles
Essays Biochem (2014) 56: 69–83.
Published: 18 August 2014
... essentially absent [ 23 ]. 1 To whom correspondence should be addressed (email dcc26@cam.ac.uk ). © The Authors Journal compilation © 2014 Biochemical Society 2014 Drosophila disease model motor neuron neurodegeneration systemic amyloidosis tauopathy toxic oligomer...
Articles
Essays Biochem (2013) 55: 119–131.
Published: 27 September 2013
... in our ‘ageing’ world. 1 To whom correspondence should be addressed (email viktor.korolchuk@ncl.ac.uk ). © The Authors Journal compilation © 2013 Biochemical Society 2013 AMPK inflammation mTOR neurodegeneration protein aggregation ROS cellular senescence Autophagy...