..., the emerging clinical multidrug resistance (MDR) has become a matter of grave concern for medical professionals. Despite advances in therapeutic interventions, it has not yet been possible to devise convincing strategies to combat antifungal resistance. Comprehensive understanding of the molecular mechanisms...

...; (v) the small multidrug resistance (SMR) family; (vi) the proteobacterial antimicrobial compound efflux (PACE) family and (vii) the p -aminobenzoyl-glutamate transporter (AbgT) family ( Figure 1 ). The latter six groups are secondary active transporters that couple efflux with ion electrochemical...

... and/or hinder any of the transport-dependent steps of the pump. In this review, we provide an overview of multidrug-resistance EPs, their inhibition strategies and the relevant findings from the various computational simulation studies reported to date with respect to deciphering the mechanism of action...