... proteins and pathways that are important for human health and disease. Heat shock protein 90 (Hsp90) is a molecular chaperone responsible for the stabilization and activation of hundreds of integral members of the cellular signaling network. Much important structural and functional work, including many...

... the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . chloroplasts molecular chaperones protease domains proteostasis signalling Components of the protein homeostasis (proteostasis) network have the crucial task of preserving proteins in their native (correctly folded) conformations...

... with hydrophobic surface pockets [ 26 ]. Arabidopsis thaliana chloroplasts molecular chaperones protein channel Plastids constitute a family of essential organelles found in plant and algal cells. Chloroplasts, the photosynthetically active plastids, fulfil vital functions not only in converting...

...Patricija van Oosten-Hawle; Annika Strauch; Martin Haslbeck All organisms rely on a conserved cellular machinery supporting and controlling the life cycle of proteins: the proteostasis network. Within this network, the main players that determine the fate of proteins are molecular chaperones...

... or damaged and need to be repaired with the help of molecular chaperones or eventually removed by specific proteases. Failure of these protein quality control mechanisms results in loss of mitochondrial function and structural integrity. Recently, novel mechanisms have been identified that support...