... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Mitochondria Mitophagy Neurodegneration Parkinsons disease PTEN induced putative kinase 1 Despite decades of ongoing work, neurodegenerative diseases are a group of mostly incurable disorders. Many of these disorders...

... transport endocytosis mitophagy neurodegeneration trafficking Neurodegenerative diseases, characterised by the progressive loss of neurons in the central nervous system, impact on the lives of millions of people around the world [ 1 ]. These disorders span a range of clinical presentations, from...

... for specific disorders. Examples of non-tailored therapeutic targets include: activation of mitochondrial biogenesis, regulation of mitophagy and mitochondrial dynamics, bypass of biochemical defects, mitochondrial replacement therapy, and hypoxia. In contrast, tailored therapies are: scavenging of toxic...

... of the Biochemical Society 2017 Aggrephagy Lysophagy Mitophagy p62/SQSTM1 Selective autophagy Xenophagy Autophagy encompasses three main pathways that mediate lysosomal degradation of intracellular cargoes. These are macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA) [ 1...

... mitochondrial quality on the organellar level. A mitochondrial unfolded protein response allows the adaptation of chaperone and protease activities. Terminally damaged mitochondria may be removed by a variation of autophagy, termed mitophagy. An understanding of the role of protein quality control...