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Keywords: microtubule
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Essays Biochem (2020) 64 (2): 263–275.
Published: 15 June 2020
... of the Biochemical Society 2020 aneuploidy fertility meiosis microfilaments microtubule oocyte Chromosome segregation is conserved throughout eukaryotic cell division – both meiotic (gametes) and mitotic (somatic) cells divide by separating their chromosomes equally into two new cells. Several...
Essays Biochem (2020) 64 (2): 371–382.
Published: 05 June 2020
...Vladimir A. Volkov Microtubules are dynamic polymers that grow and shrink through addition or loss of tubulin subunits at their ends. Microtubule ends generate mechanical force that moves chromosomes and cellular organelles, and provides mechanical tension. Recent literature describes a number...
Essays Biochem (2020) 64 (2): 299–311.
Published: 14 May 2020
... connect chromosomes to spindle microtubules and transduce forces through these connections to congress chromosomes and silence the spindle assembly checkpoint. Kinetochore-microtubule attachments are highly regulated to ensure that incorrect attachments are not prematurely stabilized, but instead released...
Essays Biochem (2019) 63 (5): 509–520.
Published: 29 July 2019
...Clare Garcin; Anne Straube Directed cell migration is critical for embryogenesis and organ development, wound healing and the immune response. Microtubules are dynamic polymers that control directional migration through a number of coordinated processes: microtubules are the tracks for long...
Essays Biochem (2018) 62 (6): 815–828.
Published: 21 November 2018
... at the distal ends of central pair microtubules. It was termed as central microtubule cap [ 17 , 22 ]. Smaller carrot-like plugs capped the A-tubules in doublet microtubules, by extending into their lumen. Distal filaments connected the plugs and the central microtubule cap to the plasma membrane...
Essays Biochem (2018) 62 (6): 803–813.
Published: 14 November 2018
...James G. Wakefield; Carolyn A. Moores; Lori Borgal; James G. Wakefield The formation of a robust, bi-polar spindle apparatus, capable of accurate chromosome segregation, is a complex process requiring the co-ordinated nucleation, sorting, stabilization and organization of microtubules (MTs). Work...
Essays Biochem (2018) 62 (6): 781–792.
Published: 14 November 2018
...James G. Wakefield; Carolyn A. Moores; Nuo Yu; Niels Galjart Microtubules are cytoskeletal elements with important cellular functions, whose dynamic behaviour and properties are in part regulated by microtubule-associated proteins (MAPs). The building block of microtubules is tubulin, a heterodimer...
Essays Biochem (2018) 62 (6): 765–780.
Published: 12 October 2018
...James G. Wakefield; Carolyn A. Moores; Corinne A. Tovey; Paul T. Conduit In this short review, we give an overview of microtubule nucleation within cells. It is nearly 30 years since the discovery of γ-tubulin, a member of the tubulin superfamily essential for proper microtubule nucleation in all...
Essays Biochem (2018) 62 (6): 737–751.
Published: 12 October 2018
...James G. Wakefield; Carolyn A. Moores; Szymon W. Manka; Carolyn A. Moores The development of cryo-electron microscopy (cryo-EM) allowed microtubules to be captured in their solution-like state, enabling decades of insight into their dynamic mechanisms and interactions with binding partners. Cryo-EM...
Essays Biochem (2013) 55: 65–78.
Published: 27 September 2013
... membrane may be the same (VAMP8). 1 email i.ganley@dundee.ac.uk © The Authors Journal compilation © 2013 Biochemical Society 2013 actin autophagosome endosome fusion lysosome maturation microtubule Rab SNARE tether The cytoskeleton has many cellular functions...