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Keywords: lysosome
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Articles
Essays Biochem (2017) 61 (6): 565–584.
Published: 12 December 2017
... lysosome mTOR Sensing of the environment is essential for cells and organisms to coordinate their metabolic activity. Nutrients, growth factors and cellular energy trigger biosynthetic pathways and thereby stimulate growth. However, in response to nutrient limitation and other cellular stresses...
Articles
Essays Biochem (2017) 61 (6): 637–647.
Published: 12 December 2017
...Jon D. Lane; Viktor I. Korolchuk; James T. Murray; Aurore Claude-Taupin; Jingyue Jia; Michal Mudd; Vojo Deretic Autophagy is conventionally described as a degradative, catabolic pathway and a tributary to the lysosomal system where the cytoplasmic material sequestered by autophagosomes gets...
Articles
Essays Biochem (2017) 61 (6): 711–720.
Published: 12 December 2017
... has led to the suggestion that the mutations underlying certain forms of PD impair autophagy. Autophagy is a degradative pathway that delivers cytoplasmic content to lysosomes for degradation and represents a major route for degradation of aggregated cellular proteins and dysfunctional organelles...
Articles
Essays Biochem (2016) 60 (2): 173–180.
Published: 15 October 2016
... by the cellular pathways of protein degradation. Lysosomes are an important site for the degradation of misfolded proteins, which are trafficked to this organelle by the pathways of macroautophagy, chaperone-mediated autophagy and endocytosis. Conversely, amyloid diseases represent a failure in proteostasis...
Articles
Essays Biochem (2013) 55: 51–64.
Published: 27 September 2013
.... Autophagosomes are subsequently targeted to the lysosome/vacuole with which they fuse to degrade their content. The formation of the autophagosome is carried out by a set of autophagy-related proteins (Atg), highly conserved from yeast to mammals. The Atg8s are Ubl (ubiquitin-like) proteins that play...
Articles
Essays Biochem (2013) 55: 65–78.
Published: 27 September 2013
... to the lysosome for degradation. Likewise, this delivery is coordinated so that only when the autophagosome is fully formed is it imparted with the information to allow it to specifically fuse with the endocytic system and deliver its contents to the lysosome. In the present chapter, I discuss our current...