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Keywords: kinase inhibitors
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Essays Biochem (2022) 66 (4): 399–412.
Published: 16 September 2022
... tumor development, cancer relapse, metastasis, and therapeutic resistance. Given that protein kinases are druggable targets for cancer therapy, tremendous efforts are being made to target CSCs with kinase inhibitors. In this review, we summarize the current knowledge and overview of the roles of protein...
Essays Biochem (2018) 62 (4): 583–593.
Published: 02 August 2018
... on the use of different forms of polytherapies (such as inhibitor combinations, multi-target kinase inhibitors and HSP90 inhibitors) as a means of combating resistance. The promise and challenges facing each of these polytherapies are elaborated with a perspective on how to effectively deploy such therapies...