... into weakly structured species, weak (or fast cycling) binding interactions, and subtle shifts in conformational dynamics. This includes intrinsically disordered proteins and regions (IDPs/IDRs) that are associated with cancer and amyloidotic neurodegenerative disease. For nucleic acids and carbohydrates...

...Samrat Mukhopadhyay; Samrat Mukhopadhyay Intrinsically disordered proteins (IDPs) defy the conventional structure–function paradigm and do not autonomously fold up into unique 3D structures for carrying out functions. They exist as rapidly interconverting conformational ensembles and are thought...

.... Correspondence: Sonia Longhi ( Sonia.longhi@univ-amu.fr ) 30 06 2022 18 08 2022 25 08 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 amyloid intrinsically disordered proteins liquid-liquid phase separations paramyxoviruses...

...Samrat Mukhopadhyay; Estella A. Newcombe; Elise Delaforge; Rasmus Hartmann-Petersen; Karen Skriver; Birthe B. Kragelund Phosphorylation is the most common post-translational modification (PTM) in eukaryotes, occurring particularly frequently in intrinsically disordered proteins (IDPs...

...Samrat Mukhopadhyay; Kurtis Mengham; Youssra Al-Hilaly; Sebastian Oakley; Kamillia Kasbi; Mahmoud B. Maina; Louise C. Serpell Tau is an intrinsically disordered protein that has the ability to self-assemble to form paired helical and straight filaments in Alzheimer’s disease, as well as the ability...

... intrinsically disordered proteins NMR spectroscopy phase separation Protein–protein interactions underlie the execution and regulation of most cellular processes. The fidelity and specificity with which these protein–protein interactions must occur to facilitate controlled changes in cellular...

...Samrat Mukhopadhyay; Jasmine Cubuk; Melissa D. Stuchell-Brereton; Andrea Soranno Intrinsically disordered proteins (IDPs) and regions (IDRs) have emerged as key players across many biological functions and diseases. Differently from structured proteins, disordered proteins lack stable structure...

... 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cellular reproduction intrinsically disordered proteins kinetochores The kinetochore (KT) is a molecular superstructure that is hundreds of MDa in size in metazoans. The KT...

... A. Volkov ( v.volkov@tudelft.nl ) 05 03 2020 01 05 2020 14 05 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 force intrinsically disordered proteins kinetochores microtubule Cells actively rearrange themselves...

..., dynamic and liquid-like assembly is emerging, in which intrinsically disordered proteins (IDPs) and proteins containing intrinsically disordered regions (IDRs) play a central role. Disorder features at all levels of chromatin organisation, from the histone tails, which are sites of extensive post...