... of the Biochemical Society 2021 cytoskeleton glia inflammation kinase inhibition LRRK2 vesicular pathways Parkinson's disease (PD) is a synucleinopathy characterized by the loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc), damage which is responsible for the cardinal...

... ) 28 04 2021 12 07 2021 15 07 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 immunometabolism inflammation macrophages NR4A1 nuclear receptors The nuclear receptor Nur77 (also known as NR4A1, NGFI-B, TR3...

... IBD inflammation Inflammatory bowel diseases (IBDs) are chronic disorders characterized by abnormal immune responses to microbes that inhabit the gastrointestinal (GI) tract. While this condition affected approximately 2 million US adults in 1999, by 2015, the incidence of IBDs had increased...

...Nan Chiang; Charles N. Serhan Today, persistent and uncontrolled inflammation is appreciated to play a pivotal role in many diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic syndrome and many other diseases of public health concern (e.g. Coronavirus Disease 2019...

.... Because they are rapidly catabolised, eicosanoids mainly act locally to the site of their production. Many eicosanoids have multiple, sometimes pleiotropic, effects on inflammation and immunity. The most widely studied is PGE 2 . Many eicosanoids have roles in the regulation of the vascular, renal...

..., or organogenesis. Furthermore, some bioactive sphingolipids are implicated in pathological processes including inflammation-associated illnesses such as atherosclerosis, rheumatoid arthritis, inflammatory bowel disease (namely Crohn’s disease and ulcerative colitis), type II diabetes, obesity, and cancer. A major...

... increase cell proliferation, migration, survival and angiogenesis. Acute inflammation produced by tissue damage stimulates ATX production and LPA signalling as a component of wound healing. If inflammation does not resolve, LPA signalling becomes maladaptive in conditions including arthritis, neurologic...

... Press Limited on behalf of the Biochemical Society 2020 hypochlorous acid inflammation myeloperoxidase oxidative stress Mammalian heme peroxidases are a family of enzymes that play a key role in the destruction of bacteria and invading pathogens in the innate immune response [ 1 , 2...

... cellular secretion inflammation lysosome mitochondria Autophagy was first implicated in the unconventional secretion of the cytosolic Acetyl CoA binding proteins Acb1 in yeast and AcbA in the slime mold Dictyostelium [ 20 , 28 ]. Sporulation in Dictyostelium is controlled by autophagy-inducing...

... in our ‘ageing’ world. 1 To whom correspondence should be addressed (email viktor.korolchuk@ncl.ac.uk ). © The Authors Journal compilation © 2013 Biochemical Society 2013 AMPK inflammation mTOR neurodegeneration protein aggregation ROS cellular senescence Autophagy...