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Keywords: epigenetics
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Essays Biochem (2022) 66 (5): 635–646.
Published: 30 September 2022
... advances in research on the molecular, biochemical and epigenetic drivers of plant immune priming. We review recent findings about the perception and signalling mechanisms controlling the onset of priming by the plant stress metabolite β-aminobutyric acid. In addition, we review the evidence for epigenetic...
Articles
Essays Biochem (2021) 65 (4): 731–740.
Published: 27 October 2021
... ]. In combination with classical in vitro experiments and bioinformatics analyses, the cell-based triplex detection methods have revealed the nature and function of several ncRNAs engaging in these non-canonical structures. epigenetics non-coding RNA RNA:DNA triplexes Genome complexity...
Articles
Essays Biochem (2021) 65 (1): 51–66.
Published: 16 April 2021
... types in the human body. The great variation in structure and function displayed by cells with identical genetic background is attributed to additional genomic information content. This includes large-scale genetic aberrations, as well as diverse epigenetic patterns that are crucial for regulating...
Articles
Essays Biochem (2020) 64 (5): 687–703.
Published: 18 August 2020
.... This review focuses on our current understanding of DNA methylation in maintaining genome integrity in mammalian cells. DNA methylation is a reversible epigenetic mark, which has been implicated in DNA damage signaling, repair and replication. Sites of DNA methylation can trigger mutations, which are drivers...
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Articles
Essays Biochem (2019) 63 (6): 797–811.
Published: 17 December 2019
...Ksenia Skvortsova; Clare Stirzaker; Phillippa Taberlay As one of the most abundant and well-studied epigenetic modifications, DNA methylation plays an essential role in normal development and cellular biology. Global alterations to the DNA methylation landscape contribute to alterations...
Articles
Essays Biochem (2019) 63 (6): 663–676.
Published: 29 November 2019
... that epigenetic mechanisms are involved in the cellular memory of these expression states. Among these, methylation of CpG sites on DNA is one of the best described modification to explain somatic inheritance. Here, we discuss the relevance of DNA methylation for the establishment and maintenance of monoallelic...
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Essays Biochem (2019) 63 (6): 639–648.
Published: 22 November 2019
...Quentin Gouil; Andrew Keniry Bisulfite sequencing is a powerful technique to detect 5-methylcytosine in DNA that has immensely contributed to our understanding of epigenetic regulation in plants and animals. Meanwhile, research on other base modifications, including 6-methyladenine and 4...
Articles
Essays Biochem (2019) 63 (6): 813–825.
Published: 14 November 2019
... 2019 23 10 2019 24 10 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 CRISPR epigenetics epigenome editing epigenomics methyltransferases synthetic biology The complex repertoire of covalent modifications of DNA...
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Essays Biochem (2019) 63 (6): 743–755.
Published: 11 October 2019
... either the CHROMOMETHYLASE (CMT) family of DNA methyltransferases or the RNA-directed DNA Methylation (RdDM) pathway [ 14–18 ]. Here we review the mechanisms, evolution, and biological roles of non-CG methylation in plants. chromatin epigenetics epigenomics methylation plant biology ©...
Articles
Essays Biochem (2019) 63 (1): 15–27.
Published: 23 April 2019
... for equal segregation of chromosomes. The centromere is characterized by both protein and DNA elements: the histone H3 variant CENP-A epigenetically defines the location of the centromere while centromeric DNA sequences are neither necessary nor sufficient for centromere function. Paradoxically, the DNA...
Articles
Essays Biochem (2016) 60 (2): 191–202.
Published: 15 October 2016
... has reverted. Such transgenerational epigenetic inheritance requires that information be stored in the germline in response to exogenous stressors. One of the most elusive questions in the field of epigenetic inheritance is the identity of such inherited factor(s). Answering this question would allow...