... 08 08 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 accelerator amyloid energy landscape inhibitor protein aggregation small-molecule modulator Amyloidosis is a class of protein-misfolding diseases characterised...

... the current state of understanding of the thermodynamics of amyloid fibrils, as well as the factors that determine the kinetics of interconversion between the various soluble, intermediate and aggregated states that a polypeptide can adopt. Before we embark on this journey through the energy landscapes...