... a role in regulating expression of genes implicated in virulence and antifungal drug resistance in pathogenic fungi. The roles of specific Mediator subunits have been investigated in several species of pathogenic fungi, particularly in the most pathogenic yeast Candida albicans . Uniquely, pathogenic...

... 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 Cancer stem cells CSC heterogeneity drug resistance The cancer stem cell (CSC) hypothesis was proposed more than four decades ago and suggests that tumor growth is fueled...

...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 cancer stem cells drug resistance hepatocellular carcinoma targeted therapy tumor-initiating cells tyrosine kinase inhibitors Therapy resistance is becoming a major problem in medicine, while...

... © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 Cancer Stem Cells Drug resistance Intratumoral heterogeneity Phenotypic plasticity Intratumor heterogeneity has emerged as an Achilles’ heel in cancer treatment. It is a multifaceted...

...Peter T. Harrison; Paul H. Huang Drug resistance remains one of the greatest challenges facing precision oncology today. Despite the vast array of resistance mechanisms that cancer cells employ to subvert the effects of targeted therapy, a deep understanding of cancer signalling networks has led...

... infection including C. difficile infection, limitations and failures have been evident due to drug resistance. Antibiotic resistance in C. difficile has been recognized as one of the most important factors to promote the infection and increase the level of severity and the recurrence rate. Several outbreaks...