... © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 crystallography drug discovery and design protein-protein interactions The discovery of new small molecule drugs is underpinned by the search for good quality chemical ‘leads’. A lead...

...@leadXpro.com ) 24 08 2017 02 10 2017 03 10 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 drug discovery and design membrane proteins Room temperature crystallography Serial crystallography X-ray Free Electron Laser...

... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . chemical biology drug discovery and design fragment based lead discovery The key feature of fragment methods...

... BY) . drug discovery and design pharmacology structure The idea to use the information from protein structure to guide the design of new therapeutic agents stems from the 1950s and 1960s when the first protein structures were elucidated by X-ray crystallography [ 1 , 2 ]. Notably, the pioneering work...

... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . antibiotics antibiotic resistance bacterial infections drug discovery and design Gram negative bacteria Gram positive bacteria Antibiotics have saved more lives than any...