... cytoskeleton/mechanics and CSC functions and the potential of cellular stiffness for specific targeting of CSCs. However, a systematic understanding of tumor cell mechanics and their role in CSCs and tumor progression is still lacking. The present review summarizes the recent progress in the alterations...

... of the Biochemical Society 2021 cytoskeleton glia inflammation kinase inhibition LRRK2 vesicular pathways Parkinson's disease (PD) is a synucleinopathy characterized by the loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc), damage which is responsible for the cardinal...

..., secondary structural changes from α-helix to β-sheet motifs leading to oligomerization, and unfolding leading to random aggregation. Key cellular outcomes are written in italics. cytoskeleton Lipid oxidation lipoxidation post translational modification protein unfolding redox signalling...

... micrographs provide 2D visualization of microtubules, and these 2D images can also be used to reconstruct the 3D structure of the polymer and any associated binding partners. In this way, the binding sites for numerous components of the microtubule cytoskeleton—including motor domains from many kinesin motors...

... cytoskeleton has an integral role in the formation of CDM domains. Using Lck as a model, we also discuss recent findings regarding cytoskeleton-dependent CDM domain functions in protein regulation. 1 To whom correspondence should be addressed (email william-rodgers@ouhsc.edu ). © The Authors Journal...