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Keywords: collagen
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Essays Biochem (2019) 63 (3): 349–364.
Published: 05 September 2019
...-binding site. They catalyze the first step of the covalent cross-linking of the extracellular matrix (ECM) proteins collagens and elastin, which contribute to ECM stiffness and mechanical properties. The role of LOX and LOXL2 in fibrosis, tumorigenesis, and metastasis, including changes...
Essays Biochem (2019) 63 (3): 297–312.
Published: 06 August 2019
...Anna Gatseva; Yuan Yan Sin; Gaia Brezzo; Tom Van Agtmael Basement membranes (BMs) are specialised extracellular matrix (ECM) structures and collagens are a key component required for BM function. While collagen IV is the major BM collagen, collagens VI, VII, XV, XVII and XVIII are also present...
Essays Biochem (2019) 63 (3): 325–335.
Published: 26 July 2019
...Pekka Rappu; Antti M. Salo; Johanna Myllyharju; Jyrki Heino Co- and post-translational hydroxylation of proline residues is critical for the stability of the triple helical collagen structure. In this review, we summarise the biology of collagen prolyl 4-hydroxylases and collagen prolyl 3...
Essays Biochem (2019) 63 (3): 377–387.
Published: 19 July 2019
...Bram Piersma; Ruud A. Bank The hallmark of fibrosis is an excessive accumulation of collagen, ultimately leading to organ failure. It has become evident that the deposited collagen also exhibits qualitative modifications. A marked modification is the increased cross-linking, leading...
Essays Biochem (2019) 63 (3): 313–323.
Published: 26 June 2019
...David J.S. Hulmes The procollagen C-propeptides of the fibrillar collagens play key roles in the intracellular assembly of procollagen molecules from their constituent polypeptides chains, and in the extracellular assembly of collagen molecules into fibrils. Here we review recent advances...