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Keywords: chemical biology
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Essays Biochem (2020) 64 (1): 1–17.
Published: 07 February 2020
... chemical biology cysteine oxidation post translational modification proteomics redox methods Oxidatively modified cysteinyl residues in proteins play an important part role in the redox regulation of cell signaling and metabolism, and the identification of the sites and modifications...
Essays Biochem (2019) 63 (2): 237–266.
Published: 15 May 2019
... Attribution License 4.0 (CC BY) . chemical biology genetic code expansion protein chemistry protein engineering unnatural amino acid Knowledge of protein function is of pivotal importance to life science research. It can guide conventional drug development programmes and lead to novel...
Essays Biochem (2017) 61 (5): 453–464.
Published: 08 November 2017
... they have had an impact in lead discovery – generating a large number of fragment-derived compounds that are in clinical trials and two medicines treating patients. In addition, we discuss some of the more recent applications of the methods in chemical biology – providing chemical tools to investigate...