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Keywords: aging
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Essays Biochem (2022) 66 (6): 797–815.
Published: 08 December 2022
... 26 09 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 aging cancer cancer suppression mechanisms development evolution somatic maintenance “Nothing in cancer makes sense except in the light of evolution” (Greaves...
Essays Biochem (2017) 61 (3): 369–377.
Published: 11 July 2017
...Thomas B.L. Kirkwood; Viktor I. Korolchuk; Alvaro Martinez Guimera; Ciaran Welsh; Piero Dalle Pezze; Nicola Fullard; Glyn Nelson; Mathilde F. Roger; Stefan A. Przyborski; Daryl P. Shanley Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing...
Essays Biochem (2017) 61 (3): 325–337.
Published: 11 July 2017
...Thomas B.L. Kirkwood; Viktor I. Korolchuk; Karolina Szczepanowska; Aleksandra Trifunovic MtDNA mutations are one of the hallmarks of ageing and age-related diseases. It is well established that somatic point mutations accumulate in mtDNA of multiple organs and tissues with increasing age...