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Keywords: aggregation
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Essays Biochem (2022) 66 (7): 817–819.
Published: 16 December 2022
... of proteins. Articles in this issue provide current trends and contemporary views on various intriguing features of these proteins involving their unique structural and dynamical characteristics, misfolding and aggregation behavior, and their phase transitions into biomolecular condensates. I hope...
Essays Biochem (2021) 65 (7): 905–912.
Published: 22 December 2021
...Yuxing Xia; Grace M. Lloyd; Benoit I. Giasson CNS pathological inclusions comprising τ or α-synuclein (αSyn) define a spectrum of neurodegenerative diseases, and these can often present concurrently in the same individuals. The aggregation of both proteins is clearly associated...
Essays Biochem (2021) 65 (7): 975–986.
Published: 22 December 2021
... (TDP-43), Fused in Sarcoma (FUS), Staufen, Pumilio and fragile-X mental retardation protein (FMRP). Therefore, we focus on two key aspects of RBP dysfunctions in neurodegeneration: protein aggregation and dysregulation of their target RNAs. Moreover, we discuss how the chaperone system responds...