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Keywords: Tethering
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Essays Biochem (2022) 66 (7): 945–958.
Published: 16 December 2022
... of viral SLiM sequences can improve affinity, allowing them to outcompete host counterparts. However, viral SLiMs are not always competitive by themselves, and tethering of two suboptimal SLiMs by a disordered linker may instead enable viral hijack. Coevolution between the SLiMs and the linker indicates...