... modifications of transcriptional regulators, histone modifications, DNA methylation, modulation of RNA polymerases, alternative transcription inititation, the Mediator complex and regulation by non-coding RNAs. In addition, on their journey from transcription to translation, mRNAs are further modulated through...

... by Chinese scientists and Essays in Biochemistry is delighted to publish this themed issue that focuses on exciting areas within RNA biology, with each review contributed by key experts from China. The textbook view of RNA often emphasizes its role as a messenger between DNA and protein, which is the key...

...Ye Wang; Guifang Jia Research on N 6 -methyladenosine (m 6 A) in recent years has revealed the complex but elegant regulatory role of this RNA modification in multiple physiological processes. The advent of m 6 A detection technologies is the basis for studying the function of this RNA modification...

...Ruth F. Ketley; Monika Gullerova The mechanisms by which RNA acts in the DNA damage response (DDR), specifically in the repair of DNA double-strand breaks (DSBs), are emerging as multifaceted and complex. Different RNA species, including but not limited to; microRNA (miRNA), long non-coding RNA...

... functionless and evolutionarily inert, being neither conserved nor removed. However, recent evidence has forced a re-evaluation of this view. Some pseudogenes, although not translated into protein, are at least transcribed into RNA. In some cases, these pseudogene transcripts are capable of influencing...