... to this work. 14 07 2022 20 09 2022 07 10 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 condensate aging condensates liquid-solid transition LLPS phase separation post-translational modifications...

.... For instance, the interaction of p53 with nuclear components could induce liquid–liquid phase separation (LLPS) and the formation of membraneless organelles. The functional or deleterious role of p53 in liquid droplets is still unclear. Functional aspects display p53 interconverting between droplets...

... pathway limit their detailed study in understanding the structure–toxicity relationship. Moreover, the precise molecular events occurring in the early stage of α-Syn aggregation process majorly remain unsolved. Recently, liquid–liquid phase separation (LLPS) of α-Syn has been designated as an alternate...

... facilitated the characterization of these discrete, dynamic complexes and how such characterization has aided the understanding of dynamic, condensed phases of phase-separating proteins with exchanging multivalent interactions. Correspondence: Julie-Forman Kay ( forman@sickkids.ca ) 20 07 2022...

...Samrat Mukhopadhyay; Si Wu; Jitao Wen; Sarah Perrett Biomolecular condensate formation via liquid–liquid phase separation (LLPS) has emerged as a ubiquitous mechanism underlying the spatiotemporal organization of biomolecules in the cell. These membraneless condensates form and disperse dynamically...

...-translational modification (PTM) that change the fate of the underlying genomic information, right through to transcription hubs, and the recently elucidated roles of IDPs and IDRs in the condensation of large regions of the genome through liquid–liquid phase separation. Correspondence: Katherine Stott...

... as they pertain to the PM, we now provide a brief introduction to lipid bilayers and the distinction between phase separation and non-random mixing in one-phase lipid mixtures. For many scientists, the lipid bilayer is at the same time both familiar in overall structure, yet also strange as a state...