...Samrat Mukhopadhyay; Pernilla Wittung-Stafshede Copper (Cu) ion dys-homeostasis and α-synclein amyloid deposits are two hallmarks of Parkinson’s disease (PD). Here, I will discuss the connections between these features, with a major focus on the role of Cu in the α-synuclein (aS) amyloid formation...

...Sarah M. Brooker; Dimitri Krainc Parkinson's disease (PD) and related neurodegenerative disorders, termed the synucleinopathies, are characterized pathologically by the accumulation of protein aggregates containing α-synuclein (aSyn), resulting in progressive neuronal loss. There is considerable...

...Zhe Yang; Zebin Li; Rohan D. Teasdale To date, mechanistic treatments targeting the initial cause of Parkinson's disease (PD) are limited due to the underlying biological cause(s) been unclear. Endosomes and their associated cellular homeostasis processes have emerged to have a significant role...

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Mitochondria Mitophagy Neurodegneration Parkinsons disease PTEN induced putative kinase 1 Despite decades of ongoing work, neurodegenerative diseases are a group of mostly incurable disorders. Many of these disorders...

...Jon D. Lane; Viktor I. Korolchuk; James T. Murray; Cansu Karabiyik; Min Jae Lee; David C. Rubinsztein Parkinson’s disease (PD) is a debilitating movement disorder typically associated with the accumulation of intracytoplasmic aggregate prone protein deposits. Over recent years, increasing evidence...