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Keywords: Mitophagy
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Essays Biochem (2021) 65 (7): 913–923.
Published: 22 December 2021
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Mitochondria Mitophagy Neurodegneration Parkinsons disease PTEN induced putative kinase 1 Despite decades of ongoing work, neurodegenerative diseases are a group of mostly incurable disorders. Many of these disorders...
Essays Biochem (2021) 65 (7): 941–948.
Published: 22 December 2021
... transport endocytosis mitophagy neurodegeneration trafficking Neurodegenerative diseases, characterised by the progressive loss of neurons in the central nervous system, impact on the lives of millions of people around the world [ 1 ]. These disorders span a range of clinical presentations, from...
Essays Biochem (2018) 62 (3): 467–481.
Published: 06 July 2018
... for specific disorders. Examples of non-tailored therapeutic targets include: activation of mitochondrial biogenesis, regulation of mitophagy and mitochondrial dynamics, bypass of biochemical defects, mitochondrial replacement therapy, and hypoxia. In contrast, tailored therapies are: scavenging of toxic...
Essays Biochem (2017) 61 (6): 609–624.
Published: 12 December 2017
... of the Biochemical Society 2017 Aggrephagy Lysophagy Mitophagy p62/SQSTM1 Selective autophagy Xenophagy A strong induction of autophagy upon nutrient starvation is conserved from yeast to mammals. This induction is mediated via the ULK1/2 complex in mammals (Atg1 complex in yeast). Under nutrient...
Essays Biochem (2016) 60 (2): 213–225.
Published: 15 October 2016
... mitochondrial quality on the organellar level. A mitochondrial unfolded protein response allows the adaptation of chaperone and protease activities. Terminally damaged mitochondria may be removed by a variation of autophagy, termed mitophagy. An understanding of the role of protein quality control...