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Keywords: HECT ligases
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Essays Biochem (2022) 66 (2): 135–145.
Published: 05 August 2022
... are members of the HECT-type family of ubiquitin ligases that utilise a unique mechanism for post-translational attachment of ubiquitin to their substrates. So why do proteasomes that already contain all the necessary machinery to recognise ubiquitinated substrates, harbour HECT ligase activity? It is now...