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Essays Biochem (2022) 66 (6): 745–752.
Published: 08 December 2022
...Ella Preger-Ben Noon; Nicolás Frankel Animal genomes are compartmentalized into insulated regulatory units named topology-associated domains (TADs). TADs insulate gene promoters from enhancers that occupy neighboring TADs. Chromosomal rearrangements that disrupt TAD structure can generate new...
Essays Biochem (2021) 65 (4): 709–721.
Published: 27 October 2021
...Khaja Mohieddin Syed; Chung-Chau Hon Enhancer RNAs (eRNAs) are non-coding RNAs transcribed from distal cis -regulatory elements (i.e. enhancers), which are stereotyped as short, rarely spliced and unstable. In fact, a non-negligible fraction of eRNAs seems to be longer, spliced and more stable...
Essays Biochem (2020) 64 (6): 883–894.
Published: 07 December 2020
...Rong Ye; Changchang Cao; Yuanchao Xue Enhancers are noncoding DNA elements that are present upstream or downstream of a gene to control its spatial and temporal expression. Specific histone modifications, such as monomethylation on histone H3 lysine 4 (H3K4me1) and H3K27ac, have been widely used...