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Keywords: Drug resistance
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Essays Biochem (2023) 67 (5): 843–851.
Published: 13 September 2023
... a role in regulating expression of genes implicated in virulence and antifungal drug resistance in pathogenic fungi. The roles of specific Mediator subunits have been investigated in several species of pathogenic fungi, particularly in the most pathogenic yeast Candida albicans . Uniquely, pathogenic...
Essays Biochem (2022) 66 (4): 371–386.
Published: 16 September 2022
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 cancer stem cells drug resistance hepatocellular carcinoma targeted therapy tumor-initiating cells tyrosine kinase inhibitors Therapy resistance is becoming a major problem in medicine, while...
Essays Biochem (2022) 66 (4): 387–398.
Published: 16 September 2022
... through which heterogeneous (genetic) drug-resistance mechanisms could evolve by allowing cells the opportunity to acquire multiple genetic mutations and/or epigenetic changes [ 41 ]. Thus, DTPs are canonical examples of phenotypic heterogeneity facilitating a long-term survival. However, many research...
Essays Biochem (2022) 66 (4): 287–289.
Published: 16 September 2022
... 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 Cancer stem cells CSC heterogeneity drug resistance The cancer stem cell (CSC) hypothesis was proposed more than four decades ago and suggests that tumor growth is fueled...
Essays Biochem (2018) 62 (4): 583–593.
Published: 02 August 2018
...Peter T. Harrison; Paul H. Huang Drug resistance remains one of the greatest challenges facing precision oncology today. Despite the vast array of resistance mechanisms that cancer cells employ to subvert the effects of targeted therapy, a deep understanding of cancer signalling networks has led...
Essays Biochem (2017) 61 (1): 81–88.
Published: 03 March 2017
... infection including C. difficile infection, limitations and failures have been evident due to drug resistance. Antibiotic resistance in C. difficile has been recognized as one of the most important factors to promote the infection and increase the level of severity and the recurrence rate. Several outbreaks...