...Shane G. Downes; Sean Doyle; Gary W. Jones; Rebecca A. Owens Antimicrobial resistance (AMR) is a major global problem and threat to humanity. The search for new antibiotics is directed towards targeting of novel microbial systems and enzymes, as well as augmenting the activity of pre-existing...

... BY) . antimicrobial resistance drug efflux mass spectrometry membrane proteins Membrane proteins are part of, or interact with, complex cellular membranes and account for approximately 30% of human proteins [ 1 ]. They are essential for diverse cellular functionalities and embody in excess of 60% of all...

...Henrietta Venter; Henrietta Venter; Michael L. Henningsen; Stephanie L. Begg The crisis of antimicrobial resistance (AMR) is one of the most serious issues facing us today. The scale of the problem is illustrated by the recent commitment of Heads of State at the UN to coordinate efforts to curb...

...Henrietta Venter; Shewli Mukerji; Mark O’Dea; Mary Barton; Roy Kirkwood; Terence Lee; Sam Abraham Gram-negative bacteria are known to cause severe infections in both humans and animals. Antimicrobial resistance (AMR) in Gram-negative bacteria is a major challenge in the treatment of clinical...

...Henrietta Venter; Mohsen Arzanlou; Wern Chern Chai; Henrietta Venter Gram-negative bacteria are responsible for a large proportion of antimicrobial-resistant infections in humans and animals. Among this class of bacteria are also some of the most successful environmental organisms. Part...

...Henrietta Venter; Mohsen Chitsaz; Melissa H. Brown Antimicrobial resistance is a current major challenge in chemotherapy and infection control. The ability of bacterial and eukaryotic cells to recognize and pump toxic compounds from within the cell to the environment before they reach their targets...