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Keywords: Amyotrophic lateral sclerosis
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Essays Biochem (2021) 65 (7): 885–904.
Published: 22 December 2021
... Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). The prominent NLRP3 inflammasome triggers include amyloid β and tau oligomers in AD, α-synuclein in PD, and superoxide dismutase (SOD1) and TAR DNA-binding protein 43 (TDP43) in ALS. NLRP3 inhibitor treatment has...
Essays Biochem (2020) 64 (5): 847–861.
Published: 20 October 2020
...Yu Sun; Annabel J. Curle; Arshad M. Haider; Gabriel Balmus Amyotrophic lateral sclerosis (ALS) is a rapidly disabling and fatal neurodegenerative disease. Due to insufficient disease-modifying treatments, there is an unmet and urgent need for elucidating disease mechanisms that occur early...