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Articles

The role of IFN-γ-signalling in response to immune checkpoint blockade therapy

Chun Wai Wong, Yang Yu Huang, Adam Hurlstone
Journal: Essays in Biochemistry
Essays Biochem (2023) EBC20230001.
https://doi.org/10.1042/EBC20230001
Published: 28 July 2023
View article titled, The role of IFN-γ-signalling in response to immune checkpoint blockade therapy
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Articles

Charge detection mass spectrometry for the analysis of viruses and virus-like particles

Lohra M. Miller, Martin F. Jarrold
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (2): 315–323.
https://doi.org/10.1042/EBC20220101
Published: 29 March 2023
View article titled, Charge detection mass spectrometry for the analysis of viruses and virus-like particles
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Articles

WNT signaling and cancer stemness

Masuko Katoh, Masaru Katoh
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 319–331.
https://doi.org/10.1042/EBC20220016
Published: 16 September 2022
View article titled, WNT signaling and cancer stemness
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Articles

Biomechanics of cancer stem cells

Xi Chen, Kai Tang, Xueyi Li, Cunyu Zhang, Ying Xin, Keming Li, Youhua Tan
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 359–369.
https://doi.org/10.1042/EBC20220014
Published: 16 September 2022
View article titled, Biomechanics of cancer stem cells
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Articles

Membrane lipid raft homeostasis is directly linked to neurodegeneration

Tobias Moll, Jack N.G. Marshall, Nikita Soni, Sai Zhang, Johnathan Cooper-Knock, Pamela J. Shaw
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (7): 999–1011.
https://doi.org/10.1042/EBC20210026
Published: 22 December 2021
View article titled, Membrane lipid raft homeostasis is directly linked to neurodegeneration
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Articles

Progesterone receptors in normal breast development and breast cancer

Sebastian Giulianelli, Caroline A. Lamb, Claudia Lanari
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (6): 951–969.
https://doi.org/10.1042/EBC20200163
Published: 26 November 2021
View article titled, Progesterone receptors in normal breast development and breast cancer
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Articles

Roles of steroid receptors in the lung and COVID-19

Damien A. Leach, Greg N. Brooke, Charlotte L. Bevan
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (6): 1025–1038.
https://doi.org/10.1042/EBC20210005
Published: 26 November 2021
View article titled, Roles of steroid receptors in the lung and COVID-19
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Articles

Nuclear receptors: from molecular mechanisms to therapeutics

Daniel E. Frigo, Maria Bondesson, Cecilia Williams
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (6): 847–856.
https://doi.org/10.1042/EBC20210020
Published: 26 November 2021
View article titled, Nuclear receptors: from molecular mechanisms to therapeutics
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Articles

SINEUPs: a novel toolbox for RNA therapeutics

Stefano Espinoza, Carlotta Bon, Paola Valentini, Bianca Pierattini, Abraham Tettey Matey, Devid Damiani, Salvatore Pulcrano, Remo Sanges, Francesca Persichetti, Hazuki Takahashi, Piero Carninci, Claudio Santoro, Diego Cotella, Stefano Gustincich
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (4): 775–789.
https://doi.org/10.1042/EBC20200114
Published: 27 October 2021
View article titled, SINEUPs: a novel toolbox for RNA therapeutics
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Articles

Targeting RNA structures in diseases with small molecules

Yanqiu Shao, Qiangfeng Cliff Zhang
Journal: Essays in Biochemistry
Essays Biochem (2020) 64 (6): 955–966.
https://doi.org/10.1042/EBC20200011
Published: 07 December 2020
View article titled, Targeting RNA structures in diseases with small molecules
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Articles

Specialized pro-resolving mediator network: an update on production and actions

Nan Chiang, Charles N. Serhan
Journal: Essays in Biochemistry
Essays Biochem (2020) 64 (3): 443–462.
https://doi.org/10.1042/EBC20200018
Published: 04 September 2020
View article titled, Specialized pro-resolving mediator network: an update on production and actions
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Articles

Correction: Base excision repair and its implications to cancer therapy

Journal: Essays in Biochemistry
Essays Biochem (2020) 64 (5): 845.
https://doi.org/10.1042/EBC20200013_COR
Published: 29 July 2020
View article titled, Correction: Base excision repair and its implications to cancer therapy
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Articles

Base excision repair and its implications to cancer therapy

Gabrielle J. Grundy, Jason L. Parsons
Journal: Essays in Biochemistry
Essays Biochem (2020) 64 (5): 831–843.
https://doi.org/10.1042/EBC20200013
Published: 10 July 2020
View article titled, Base excision repair and its implications to cancer therapy
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Articles

Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining

Antonia Kefala Stavridi, Robert Appleby, Shikang Liang, Tom L. Blundell, Amanda K. Chaplin
Journal: Essays in Biochemistry
Essays Biochem (2020) 64 (5): 791–806.
https://doi.org/10.1042/EBC20190092
Published: 24 June 2020
View article titled, Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining
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Articles

Basement membrane collagens and disease mechanisms

Anna Gatseva, Yuan Yan Sin, Gaia Brezzo, Tom Van Agtmael
Journal: Essays in Biochemistry
Essays Biochem (2019) 63 (3): 297–312.
https://doi.org/10.1042/EBC20180071
Published: 06 August 2019
View article titled, Basement membrane collagens and disease mechanisms
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Articles

Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance

Peter T. Harrison, Paul H. Huang
Journal: Essays in Biochemistry
Essays Biochem (2018) 62 (4): 583–593.
https://doi.org/10.1042/EBC20180016
Published: 02 August 2018
View article titled, Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance
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Articles

Clinical syndromes associated with mtDNA mutations: where we stand after 30 years

Valerio Carelli, Chiara La Morgia
Journal: Essays in Biochemistry
Essays Biochem (2018) 62 (3): 235–254.
https://doi.org/10.1042/EBC20170097
Published: 20 July 2018
View article titled, Clinical syndromes associated with mtDNA mutations: where we stand after 30 years
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Articles

Coenzyme Q 10 deficiencies: pathways in yeast and humans

Agape M. Awad, Michelle C. Bradley, Lucía Fernández-del-Río, Anish Nag, Hui S. Tsui, Catherine F. Clarke
Journal: Essays in Biochemistry
Essays Biochem (2018) 62 (3): 361–376.
https://doi.org/10.1042/EBC20170106
Published: 06 July 2018
View article titled, Coenzyme Q 10 deficiencies: pathways in yeast and humans
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Articles

Natural history of mitochondrial disorders: a systematic review

Nandaki Keshavan, Shamima Rahman
Journal: Essays in Biochemistry
Essays Biochem (2018) 62 (3): 423–442.
https://doi.org/10.1042/EBC20170108
Published: 06 July 2018
View article titled, Natural history of mitochondrial disorders: a systematic review
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Articles

Advances in methods for reducing mitochondrial DNA disease by replacing or manipulating the mitochondrial genome

Pavandeep K. Rai, Lyndsey Craven, Kurt Hoogewijs, Oliver M. Russell, Robert N. Lightowlers
Journal: Essays in Biochemistry
Essays Biochem (2018) 62 (3): 455–465.
https://doi.org/10.1042/EBC20170113
Published: 27 June 2018
View article titled, Advances in methods for reducing mitochondrial DNA disease by replacing or manipulating the mitochondrial genome
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Articles

Exosomes and cardiovascular cell–cell communication

Adam J. Poe, Anne A. Knowlton
Journal: Essays in Biochemistry
Essays Biochem (2018) 62 (2): 193–204.
https://doi.org/10.1042/EBC20170081
Published: 01 May 2018
View article titled, Exosomes and cardiovascular cell–cell communication
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Articles

Dysregulation of autophagy as a common mechanism in lysosomal storage diseases

Elena Seranova, Kyle J. Connolly, Malgorzata Zatyka, Tatiana R. Rosenstock, Timothy Barrett, Richard I. Tuxworth, Sovan Sarkar
Journal: Essays in Biochemistry
Essays Biochem (2017) 61 (6): 733–749.
https://doi.org/10.1042/EBC20170055
Published: 12 December 2017
View article titled, Dysregulation of autophagy as a common mechanism in lysosomal storage diseases
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Articles

Interplay of autophagy, receptor tyrosine kinase signalling and endocytic trafficking

Jane Fraser, Ainara G. Cabodevilla, Joanne Simpson, Noor Gammoh
Journal: Essays in Biochemistry
Essays Biochem (2017) 61 (6): 597–607.
https://doi.org/10.1042/EBC20170091
Published: 12 December 2017
View article titled, Interplay of autophagy, receptor tyrosine kinase signalling and endocytic trafficking
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Articles

Fragment-based drug discovery and its application to challenging drug targets

Amanda J. Price, Steven Howard, Benjamin D. Cons
Journal: Essays in Biochemistry
Essays Biochem (2017) 61 (5): 475–484.
https://doi.org/10.1042/EBC20170029
Published: 08 November 2017
View article titled, Fragment-based drug discovery and its application to challenging drug targets
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Articles

Current perspectives in fragment-based lead discovery (FBLD)

Bas Lamoree, Roderick E. Hubbard
Journal: Essays in Biochemistry
Essays Biochem (2017) 61 (5): 453–464.
https://doi.org/10.1042/EBC20170028
Published: 08 November 2017
View article titled, Current perspectives in fragment-based lead discovery (FBLD)
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Articles

Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders

Scott J. Hughes, Alessio Ciulli
Journal: Essays in Biochemistry
Essays Biochem (2017) 61 (5): 505–516.
https://doi.org/10.1042/EBC20170041
Published: 08 November 2017
View article titled, Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders
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Articles

NMR in structure-based drug design

Marta G. Carneiro, Eiso AB, Stephan Theisgen, Gregg Siegal
Journal: Essays in Biochemistry
Essays Biochem (2017) 61 (5): 485–493.
https://doi.org/10.1042/EBC20170037
Published: 08 November 2017
View article titled, NMR in structure-based drug design
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Articles

Structure-based drug design: aiming for a perfect fit

Rob L.M. van Montfort, Paul Workman
Journal: Essays in Biochemistry
Essays Biochem (2017) 61 (5): 431–437.
https://doi.org/10.1042/EBC20170052
Published: 08 November 2017
View article titled, Structure-based drug design: aiming for a perfect fit
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Articles

Protein degradation: a validated therapeutic strategy with exciting prospects

Honorine Lebraud, Tom D. Heightman
Journal: Essays in Biochemistry
Essays Biochem (2017) 61 (5): 517–527.
https://doi.org/10.1042/EBC20170030
Published: 02 October 2017
View article titled, Protein degradation: a validated therapeutic strategy with exciting prospects
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Articles

Polishing the tarnished silver bullet: the quest for new antibiotics

Mark A.T. Blaskovich, Mark S. Butler, Matthew A. Cooper
Journal: Essays in Biochemistry
Essays Biochem (2017) 61 (1): 103–114.
https://doi.org/10.1042/EBC20160077
Published: 03 March 2017
View article titled, Polishing the tarnished silver bullet: the quest for new antibiotics
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Articles

Insights into drug resistance mechanisms in Clostridium difficile

Phurt Harnvoravongchai, Methinee Pipatthana, Surang Chankhamhaengdecha, Tavan Janvilisri
Journal: Essays in Biochemistry
Essays Biochem (2017) 61 (1): 81–88.
https://doi.org/10.1042/EBC20160062
Published: 03 March 2017
View article titled, Insights into drug resistance mechanisms in Clostridium difficile
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Articles

Microfluidics: innovative approaches for rapid diagnosis of antibiotic-resistant bacteria

Amornrat Aroonnual, Tavan Janvilisri, Puey Ounjai, Surang Chankhamhaengdecha
Journal: Essays in Biochemistry
Essays Biochem (2017) 61 (1): 91–101.
https://doi.org/10.1042/EBC20160059
Published: 03 March 2017
View article titled, Microfluidics: innovative approaches for rapid diagnosis of antibiotic-resistant bacteria
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Articles

Resistance to antifungal therapies

Rajendra Prasad, Atanu Banerjee, Abdul Haseeb Shah
Journal: Essays in Biochemistry
Essays Biochem (2017) 61 (1): 157–166.
https://doi.org/10.1042/EBC20160067
Published: 03 March 2017
View article titled, Resistance to antifungal therapies
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