Grundy, G.J. and Parsons, J.L. (2020) Base excision repair and its implications to cancer therapy. Essays Biochem.https://doi.org/10.1042/EBC20200013
During the production process errors were introduced into Table 1. The correct version of Table 1 appears here.
Table 1
DNA glycosylases: substrates, inhibitors and synthetic lethal partners
| DNA Glycosylase . | Substrate . | Inhibitor . | Synthetic lethal partner . |
|---|---|---|---|
| Monofunctional | |||
| UNG | |||
| Uracil DNA glycosylase | Uracil | APOBEC3B | |
| SMUG1 | |||
| Single-strand selective monofunctional uracil DNA glycosylase | Uracil, 5-formyluracil, 5-hydroxyuracil and 5-hydroxymethyluracil | ||
| TDG | |||
| G/T Mismatch specific thymine DNA glycosylase | 5-Formylcytosine and 5-carboxylcytosine in CpG. G:T and U:T mismatches | ||
| MBD4 | |||
| methyl-CpG binding domain protein 4 | G:T mismatches within methylated and unmethylated CpG sites. Uracil or 5-fluorouracil in G:U mismatches | ||
| MPG | |||
| N-methylpurine DNA glycosylase | 3-methyladenine, and 7-methylguanine | ||
| MUTYH | |||
| Adenine DNA glycosylase | 7,8-Dihydro-8-oxoguanine (8-oxoG):adenine | ||
| Bifunctional | |||
| NTH1 | |||
| Endonuclease III-like protein 1 | Oxidised pyrimidines, thymine glycol | ||
| OGG1 | |||
| 8-oxoguanine DNA glycosylase 1 | 8-OxoG, formamidopyrimidine (Fapy)G | O8 | MMR deficiency |
| SU0268 | |||
| TH5487 | |||
| Endonuclease VIII-like | |||
| NEIL1 | Thymine glycol, Fapy, 5-hydroxyuracil | 2TX | FANCG |
| NEIL2 | 5-Hydroxyuracil | ||
| NEIL3 | Spiroiminodihydantoin and guanidinohydantoin |
| DNA Glycosylase . | Substrate . | Inhibitor . | Synthetic lethal partner . |
|---|---|---|---|
| Monofunctional | |||
| UNG | |||
| Uracil DNA glycosylase | Uracil | APOBEC3B | |
| SMUG1 | |||
| Single-strand selective monofunctional uracil DNA glycosylase | Uracil, 5-formyluracil, 5-hydroxyuracil and 5-hydroxymethyluracil | ||
| TDG | |||
| G/T Mismatch specific thymine DNA glycosylase | 5-Formylcytosine and 5-carboxylcytosine in CpG. G:T and U:T mismatches | ||
| MBD4 | |||
| methyl-CpG binding domain protein 4 | G:T mismatches within methylated and unmethylated CpG sites. Uracil or 5-fluorouracil in G:U mismatches | ||
| MPG | |||
| N-methylpurine DNA glycosylase | 3-methyladenine, and 7-methylguanine | ||
| MUTYH | |||
| Adenine DNA glycosylase | 7,8-Dihydro-8-oxoguanine (8-oxoG):adenine | ||
| Bifunctional | |||
| NTH1 | |||
| Endonuclease III-like protein 1 | Oxidised pyrimidines, thymine glycol | ||
| OGG1 | |||
| 8-oxoguanine DNA glycosylase 1 | 8-OxoG, formamidopyrimidine (Fapy)G | O8 | MMR deficiency |
| SU0268 | |||
| TH5487 | |||
| Endonuclease VIII-like | |||
| NEIL1 | Thymine glycol, Fapy, 5-hydroxyuracil | 2TX | FANCG |
| NEIL2 | 5-Hydroxyuracil | ||
| NEIL3 | Spiroiminodihydantoin and guanidinohydantoin |
© 2020 The Author(s).
2020
This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
