Radical rearrangement and transfer reactions play an important role in the chemical modifications of proteins in vivo and in vitro. These reactions depend on protein sequence, as well as structure and dynamics. Frequently, these reactions have well-defined precedents in the organic chemistry literature, but their occurrence in proteins provides a stage for a number of novel and, perhaps, unexpected reaction products. This essay will provide an overview over a few representative examples of radical rearrangement and transfer reactions.

Keywords:
3-methyleneindolenine, free radicals, protein oxidation, radical cations, tryptophan, tyrosine
Subjects:
Biotechnology, Chemical Biology, Post-Translational Modifications
© 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2020
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