Parkinson’s disease (PD) is a debilitating movement disorder typically associated with the accumulation of intracytoplasmic aggregate prone protein deposits. Over recent years, increasing evidence has led to the suggestion that the mutations underlying certain forms of PD impair autophagy. Autophagy is a degradative pathway that delivers cytoplasmic content to lysosomes for degradation and represents a major route for degradation of aggregated cellular proteins and dysfunctional organelles. Autophagy up-regulation is a promising therapeutic strategy that is being explored for its potential to protect cells against the toxicity of aggregate-prone proteins in neurodegenerative diseases. Here, we describe how the mutations in different subtypes of PD can affect different stages of autophagy.
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December 2017
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This issue of Essays in Biochemistry covers a range of topics in autophagy signalling, touching on emerging new details on the mechanisms of autophagy regulation, novel aspects of selective autophagy and how autophagy functions in organelle homeostasis. It also looks at how autophagy research is leading to better understanding of human disease and plant biology that can be exploited for the benefit of society. Cover image credit: Kateryna Kon (Shutterstock: 494829457)
Review Article|
December 12 2017
Autophagy impairment in Parkinson’s disease
Cansu Karabiyik;
Cansu Karabiyik
1Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, U.K.
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Min Jae Lee;
2Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Korea
Correspondence: David C. Rubinsztein (dcr1000@cam.ac.uk) or Min Jae Lee (minjlee@snu.ac.kr)
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David C. Rubinsztein
1Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, U.K.
3UK Dementia Research Institute, Cambridge Biomedical Campus, Cambridge Biomedical Campus, Hills Road, Cambridge, U.K.
Correspondence: David C. Rubinsztein (dcr1000@cam.ac.uk) or Min Jae Lee (minjlee@snu.ac.kr)
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Publisher: Portland Press Ltd
Received:
August 21 2017
Revision Received:
October 14 2017
Accepted:
October 24 2017
Online ISSN: 1744-1358
Print ISSN: 0071-1365
© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2017
Essays Biochem (2017) 61 (6): 711–720.
Article history
Received:
August 21 2017
Revision Received:
October 14 2017
Accepted:
October 24 2017
Citation
Jon D. Lane, Viktor I. Korolchuk, James T. Murray, Cansu Karabiyik, Min Jae Lee, David C. Rubinsztein; Autophagy impairment in Parkinson’s disease. Essays Biochem 12 December 2017; 61 (6): 711–720. doi: https://doi.org/10.1042/EBC20170023
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