The loss of muscle mass and weakness that accompanies ageing is a major contributor to physical frailty and loss of independence in older people. A failure of muscle to adapt to physiological stresses such as exercise is seen with ageing and disruption of redox regulated processes and stress responses are recognized to play important roles in theses deficits. The role of redox regulation in control of specific stress responses, including the generation of heat shock proteins (HSPs) by muscle appears to be particularly important and affected by ageing. Transgenic and knockout studies in experimental models in which redox and HSP responses were modified have demonstrated the importance of these processes in maintenance of muscle mass and function during ageing. New data also indicate the potential of these processes to interact with and influence ageing in other tissues. In particular the roles of redox signalling and HSPs in regulation of inflammatory pathways appears important in their impact on organismal ageing. This review will briefly indicate the importance of this area and demonstrate how an understanding of the manner in which redox and stress responses interact and how they may be controlled offers considerable promise as an approach to ameliorate the major functional consequences of ageing of skeletal muscle (and potentially other tissues) in man.
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July 2017
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This issue explores the molecular and cellular mechanisms which underpin the process of ageing. Guest Edited by Professor Tom Kirkwood, CBE and Dr Viktor Korolchuk of the Newcastle University Institute for Ageing and Health, the issue includes reviews on mechanisms involved in ageing include genome instability and redox stress as well as insights from systems biology and approaches for extending the human healthspan. - PDF Icon PDF LinkTable of Contents
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Review Article|
July 11 2017
The role of attenuated redox and heat shock protein responses in the age-related decline in skeletal muscle mass and function
Anne McArdle;
Anne McArdle
1MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8TX, U.K.
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Malcolm J. Jackson
1MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8TX, U.K.
Correspondence: Anne McArdle (mdcr02@liverpool.ac.uk)
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Publisher: Portland Press Ltd
Received:
February 08 2017
Revision Received:
April 29 2017
Accepted:
May 11 2017
Online ISSN: 1744-1358
Print ISSN: 0071-1365
© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2017
Essays Biochem (2017) 61 (3): 339–348.
Article history
Received:
February 08 2017
Revision Received:
April 29 2017
Accepted:
May 11 2017
Citation
Thomas B.L. Kirkwood, Viktor I. Korolchuk, Anne McArdle, Malcolm J. Jackson; The role of attenuated redox and heat shock protein responses in the age-related decline in skeletal muscle mass and function. Essays Biochem 11 July 2017; 61 (3): 339–348. doi: https://doi.org/10.1042/EBC20160088
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