Bacterial transition metal homoeostasis or simply ‘metallostasis’ describes the process by which cells control the intracellular availability of functionally required metal cofactors, from manganese (Mn) to zinc (Zn), avoiding both metal deprivation and toxicity. Metallostasis is an emerging aspect of the vertebrate host–pathogen interface that is defined by a ‘tug-of-war’ for biologically essential metals and provides the motivation for much recent work in this area. The host employs a number of strategies to starve the microbial pathogen of essential metals, while for others attempts to limit bacterial infections by leveraging highly competitive metals. Bacteria must be capable of adapting to these efforts to remodel the transition metal landscape and employ highly specialized metal sensing transcriptional regulators, termed metalloregulatory proteins,and metallochaperones, that allocate metals to specific destinations, to mediate this adaptive response. In this essay, we discuss recent progress in our understanding of the structural mechanisms and metal specificity of this adaptive response, focusing on energy-requiring metallochaperones that play roles in the metallocofactor active site assembly in metalloenzymes and metallosensors, which govern the systems-level response to metal limitation and intoxication.
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May 2017
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A His6 motif of the human calprotectin heterodimer with a bound Mn(II) ion. In this issue of Essays in Biochemistry, Neumann et al. look at the how pathogenic Neisseria species exploit host metaloproteins, such as calprotectin, to acquire essential transition metal ions. For further details, see pages 211-223. Image kindly provided by Elizabeth M. Nolan (Massachusetts Institute of Technology). - PDF Icon PDF LinkTable of Contents
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Review Article|
May 09 2017
Metallochaperones and metalloregulation in bacteria
Daiana A. Capdevila;
Daiana A. Capdevila
1Department of Chemistry, Indiana University, Bloomington, IN 47405-7102, U.S.A.
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Katherine A. Edmonds;
Katherine A. Edmonds
1Department of Chemistry, Indiana University, Bloomington, IN 47405-7102, U.S.A.
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David P. Giedroc
1Department of Chemistry, Indiana University, Bloomington, IN 47405-7102, U.S.A.
2Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, U.S.A.
Correspondence: David P. Giedroc (giedroc@indiana.edu)
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Publisher: Portland Press Ltd
Received:
December 26 2016
Revision Received:
February 23 2017
Accepted:
February 27 2017
Online ISSN: 1744-1358
Print ISSN: 0071-1365
© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2017
Essays Biochem (2017) 61 (2): 177–200.
Article history
Received:
December 26 2016
Revision Received:
February 23 2017
Accepted:
February 27 2017
Citation
Stephen J. Lippard, Jeremy M. Berg, Daiana A. Capdevila, Katherine A. Edmonds, David P. Giedroc; Metallochaperones and metalloregulation in bacteria. Essays Biochem 9 May 2017; 61 (2): 177–200. doi: https://doi.org/10.1042/EBC20160076
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