The complexity of designed bionano-scale architectures is rapidly increasing mainly due to the expanding field of DNA-origami technology and accurate protein design approaches. The major advantage offered by polypeptide nanostructures compared with most other polymers resides in their highly programmable complexity. Proteins allow in vivo formation of well-defined structures with a precise spatial arrangement of functional groups, providing extremely versatile nano-scale scaffolds. Extending beyond existing proteins that perform a wide range of functions in biological systems, it became possible in the last few decades to engineer and predict properties of completely novel protein folds, opening the field of protein nanostructure design. This review offers an overview on rational and computational design approaches focusing on the main achievements of novel protein nanostructure design.
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November 2016
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Illustration of an agent-based model of engineered bacteria containing synthetic genetic circuits that enable communication via diffusive quorum sensing molecules. In this issue, Thomas Gorochowski reviews the use of agent-based modelling in synthetic biology and presents examples of the synthetic cellular systems amenable to this technique. For more information, please see pp. 325-336. Image provided by Thomas Gorochowski.
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Review Article|
November 30 2016
Towards designing new nano-scale protein architectures
Jana Aupič;
Jana Aupič
1
*Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia
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Fabio Lapenta;
Fabio Lapenta
1
*Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia
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Žiga Strmšek;
Žiga Strmšek
1
*Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia
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Roman Jerala
*Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia
†EN-FIST Centre of Excellence, Trg OF 13, 1000 Ljubljana, Slovenia
Correspondence (email roman.jerala@ki.si).
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Publisher: Portland Press Ltd
Received:
January 21 2016
Revision Received:
August 11 2016
Accepted:
August 18 2016
Online ISSN: 1744-1358
Print ISSN: 0071-1365
© 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
2016
Essays Biochem (2016) 60 (4): 315–324.
Article history
Received:
January 21 2016
Revision Received:
August 11 2016
Accepted:
August 18 2016
Citation
Vitor B. Pinheiro, Jana Aupič, Fabio Lapenta, Žiga Strmšek, Roman Jerala; Towards designing new nano-scale protein architectures. Essays Biochem 30 November 2016; 60 (4): 315–324. doi: https://doi.org/10.1042/EBC20160018
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