Nature has evolved several mechanisms to detoxify intracellular protein aggregates that arise upon proteotoxic challenges. These include the controlled deposition of misfolded proteins at distinct cellular sites, the protein disaggregation and refolding by molecular chaperones and/or degradation of misfolded and aggregated protein species by cellular clearance pathways. In this article, we discuss cellular the strategies of prokaroytes and eukaryotes to control protein aggregation.
Keywords:
aggresome,
amyloid,
autophagy,
chaperones,
degradation,
deposition,
disaggregase,
misfolding,
polyQ,
proteasome
© 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2016
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