Systems biology is an integrative discipline connecting the molecular components within a single biological scale and also among different scales (e.g. cells, tissues and organ systems) to physiological functions and organismal phenotypes through quantitative reasoning, computational models and high-throughput experimental technologies. Systems biology uses a wide range of quantitative experimental and computational methodologies to decode information flow from genes, proteins and other subcellular components of signaling, regulatory and functional pathways to control cell, tissue, organ and organismal level functions. The computational methods used in systems biology provide systems-level insights to understand interactions and dynamics at various scales, within cells, tissues, organs and organisms. In recent years, the systems biology framework has enabled research in quantitative and systems pharmacology and precision medicine for complex diseases. Here, we present a brief overview of current experimental and computational methods used in systems biology.
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October 2018
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Cover Image
This issue of Essays in Biochemistry provides an overview of current research at the interface of the disciplines of biochemistry and systems biology and also looks ahead to future interactions. The cover image, based on Figure 2 in the systems biology primer article by Tavassoly et al., depicts the current computational methods used to analyze different types of high-throughput as well as small scale in-depth experimental data in systems biology. For further details, see pages 487-500.
Review Article|
October 04 2018
Systems biology primer: the basic methods and approaches
Iman Tavassoly;
Iman Tavassoly
1Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai, New York, NY 10029, U.S.A.
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Joseph Goldfarb;
Joseph Goldfarb
1Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai, New York, NY 10029, U.S.A.
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Ravi Iyengar
1Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai, New York, NY 10029, U.S.A.
Correspondence: Ravi Iyengar (ravi.iyengar@mssm.edu)
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Publisher: Portland Press Ltd
Received:
July 19 2018
Revision Received:
August 22 2018
Accepted:
August 24 2018
Online ISSN: 1744-1358
Print ISSN: 0071-1365
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Essays Biochem (2018) 62 (4): 487–500.
Article history
Received:
July 19 2018
Revision Received:
August 22 2018
Accepted:
August 24 2018
Citation
Iman Tavassoly, Joseph Goldfarb, Ravi Iyengar; Systems biology primer: the basic methods and approaches. Essays Biochem 26 October 2018; 62 (4): 487–500. doi: https://doi.org/10.1042/EBC20180003
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