Chaperone-mediated autophagy (CMA) is a selective form of autophagy in which cytosolic proteins bearing a pentapeptide motif biochemically related to the KFERQ sequence, are recognized by the heat shock protein family A member 8 (HSPA8) chaperone, delivered to the lysomal membrane, and directly translocated across the lysosomal membrane by a protein complex containing lysosomal associated membrane protein 2a (Lamp2a). Since its discovery over two decades ago, the importance of this pathway in cell proteostasis has been made increasingly apparent. Deregulation of this pathway has been implicated in a variety of diseases and conditions, including lysosomal storage diseases, cancer, neurodegeneration and even aging. Here, we describe the main molecular features of the pathway, its regulation, cross-talk with other degradation pathways and importance in disease.
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December 2017
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This issue of Essays in Biochemistry covers a range of topics in autophagy signalling, touching on emerging new details on the mechanisms of autophagy regulation, novel aspects of selective autophagy and how autophagy functions in organelle homeostasis. It also looks at how autophagy research is leading to better understanding of human disease and plant biology that can be exploited for the benefit of society. Cover image credit: Kateryna Kon (Shutterstock: 494829457)
Review Article|
December 12 2017
Molecular control of chaperone-mediated autophagy
Steve Catarino;
Steve Catarino
1Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
2CNC.IBILI, University of Coimbra, Coimbra, Portugal
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Paulo Pereira;
Paulo Pereira
1Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
2CNC.IBILI, University of Coimbra, Coimbra, Portugal
3Chronic Diseases Research Center (CEDOC), NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa, Portugal
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Henrique Girão
1Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
2CNC.IBILI, University of Coimbra, Coimbra, Portugal
Correspondence: Henrique Girão (hmgirao@fmed.uc.pt)
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Essays Biochem (2017) 61 (6): 663–674.
Article history
Received:
August 17 2017
Revision Received:
October 23 2017
Accepted:
November 01 2017
Citation
Jon D. Lane, Viktor I. Korolchuk, James T. Murray, Steve Catarino, Paulo Pereira, Henrique Girão; Molecular control of chaperone-mediated autophagy. Essays Biochem 12 December 2017; 61 (6): 663–674. doi: https://doi.org/10.1042/EBC20170057
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