The emergence of antibiotic-resistant bacteria has become a major global health concern. Rapid and accurate diagnostic strategies to determine the antibiotic susceptibility profile prior to antibiotic prescription and treatment are critical to control drug resistance. The standard diagnostic procedures for the detection of antibiotic-resistant bacteria, which rely mostly on phenotypic characterization, are time consuming, insensitive and often require skilled personnel, making them unsuitable for point-of-care (POC) diagnosis. Various molecular techniques have therefore been implemented to help speed up the process and increase sensitivity. Over the past decade, microfluidic technology has gained great momentum in medical diagnosis as a series of fluid handling steps in a laboratory can be simplified and miniaturized on to a small platform, allowing marked reduction of sample amount, high portability and tremendous possibility for integration with other detection technologies. These advantages render the microfluidic system a great candidate to be developed into an easy-to-use sample-to-answer POC diagnosis suitable for application in remote clinical settings. This review provides an overview of the current development of microfluidic technologies for the nucleic acid based and phenotypic-based detections of antibiotic resistance.
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March 2017
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A representative image of a microfl uidic device for antibiotic susceptibility testing. In the device, bacterial cells are immobilized enabling realtime monitoring of bacterial morphology. Upon addition of antibiotics, susceptible cells die, while the resistant bacteria survive. For more information please see the article by Aroonnual et al. (pages 91-101). - PDF Icon PDF LinkTable of Contents
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Review Article|
March 03 2017
Microfluidics: innovative approaches for rapid diagnosis of antibiotic-resistant bacteria
Amornrat Aroonnual;
Amornrat Aroonnual
1Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
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Tavan Janvilisri;
Tavan Janvilisri
2Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
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Puey Ounjai;
Puey Ounjai
3Department of Biology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
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Surang Chankhamhaengdecha
3Department of Biology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
Correspondence: Surang Chankhamhaengdecha (surang.cha@mahidol.ac.th)
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Publisher: Portland Press Ltd
Received:
October 21 2016
Revision Received:
January 14 2017
Accepted:
January 18 2017
Online ISSN: 1744-1358
Print ISSN: 0071-1365
© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2017
Essays Biochem (2017) 61 (1): 91–101.
Article history
Received:
October 21 2016
Revision Received:
January 14 2017
Accepted:
January 18 2017
Citation
Henrietta Venter, Amornrat Aroonnual, Tavan Janvilisri, Puey Ounjai, Surang Chankhamhaengdecha; Microfluidics: innovative approaches for rapid diagnosis of antibiotic-resistant bacteria. Essays Biochem 3 March 2017; 61 (1): 91–101. doi: https://doi.org/10.1042/EBC20160059
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