The evolution of antifungal resistance among fungal pathogens has rendered the limited arsenal of antifungal drugs futile. Considering the recent rise in the number of nosocomial fungal infections in immunocompromised patients, the emerging clinical multidrug resistance (MDR) has become a matter of grave concern for medical professionals. Despite advances in therapeutic interventions, it has not yet been possible to devise convincing strategies to combat antifungal resistance. Comprehensive understanding of the molecular mechanisms of antifungal resistance is essential for identification of novel targets that do not promote or delay emergence of drug resistance. The present study discusses features and limitations of the currently available antifungals, mechanisms of antifungal resistance and highlights the emerging therapeutic strategies that could be deployed to combat MDR.
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March 2017
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A representative image of a microfl uidic device for antibiotic susceptibility testing. In the device, bacterial cells are immobilized enabling realtime monitoring of bacterial morphology. Upon addition of antibiotics, susceptible cells die, while the resistant bacteria survive. For more information please see the article by Aroonnual et al. (pages 91-101). - PDF Icon PDF LinkTable of Contents
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Review Article|
March 03 2017
Resistance to antifungal therapies
Rajendra Prasad;
1Institute of Integrative Sciences and Health and Institute of Biotechnology, Amity University Haryana, Amity Education Valley, Gurgaon, India
Correspondence: Rajendra Prasad (rprasad@ggn.amity.edu)
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Atanu Banerjee;
Atanu Banerjee
2School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
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Abdul Haseeb Shah
Abdul Haseeb Shah
3Department of Bioresources, University of Kashmir, Srinagar, India
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Publisher: Portland Press Ltd
Received:
November 28 2016
Revision Received:
January 02 2017
Accepted:
January 05 2017
Online ISSN: 1744-1358
Print ISSN: 0071-1365
© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2017
Essays Biochem (2017) 61 (1): 157–166.
Article history
Received:
November 28 2016
Revision Received:
January 02 2017
Accepted:
January 05 2017
Citation
Henrietta Venter, Rajendra Prasad, Atanu Banerjee, Abdul Haseeb Shah; Resistance to antifungal therapies. Essays Biochem 3 March 2017; 61 (1): 157–166. doi: https://doi.org/10.1042/EBC20160067
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