Metabolomics is the study of small molecules present in biological samples. In recent years it has become evident that such small molecules, called metabolites, play a key role in the development of disease states. Furthermore, metabolomic applications can reveal information about alterations in certain metabolic pathways under different conditions. Data acquisition in metabolomics is usually performed using nuclear magnetic resonance (NMR)-based approaches or mass spectrometry (MS)-based approaches with a more recent trend including the application of multiple platforms in order to maximise the coverage in terms of metabolites measured. The application of metabolomics is rapidly increasing and the present review will highlight applications in nutrition research.
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December 2016
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The metabolome consists of a collection of biomolecules present in cells, tissues, or body fl uids in a certain moment or physiological situation. It refl ects an individual’s genetic background and is modulated by environmental factors such as diet and physical activity. Metabolomics is the comprehensive study of the entire metabolome, made possible due to advances in the areas of mass spectrometry and nuclear magnetic resonance, allowing the systematic investigation of the metabolome in various biological specimens. Metabolic profi les generated through metabolomic approaches can offer insights into pathophysiological mechanisms associated with nutrient dependent dysfunction or disease and targeted therapeutic approaches. Image supplied by Philip Newsholme and Rodrigo Carless - PDF Icon PDF LinkTable of Contents
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Review Article|
December 15 2016
Metabolomics in nutrition research–a powerful window into nutritional metabolism
Lorraine Brennan
1UCD Institute of Food and Health, University College Dublin, Belfield, Dublin 4, Ireland and Human Nutrition Research Centre and Institute for Health and Society, Newcastle University, Newcastle upon Tyne, U.K.
Correspondence: Lorraine Brennan (lorraine.brennan@ucd.ie)
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Publisher: Portland Press Ltd
Received:
February 26 2016
Revision Received:
October 27 2016
Accepted:
October 29 2016
Online ISSN: 1744-1358
Print ISSN: 0071-1365
© 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
2016
Essays Biochem (2016) 60 (5): 451–458.
Article history
Received:
February 26 2016
Revision Received:
October 27 2016
Accepted:
October 29 2016
Citation
Philip Newsholme, Lorraine Brennan; Metabolomics in nutrition research–a powerful window into nutritional metabolism. Essays Biochem 15 December 2016; 60 (5): 451–458. doi: https://doi.org/10.1042/EBC20160029
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