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Keywords: phase separation
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Emerg Top Life Sci (2023) 7 (1): 55–65.
Published: 06 January 2023
...@uth.tmc.edu ) 15 11 2022 14 12 2022 20 12 2022 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology 2023 cryo-EM lipid rafts liquid-disordered liquid-ordered nanodomains phase separation...
Emerg Top Life Sci (2020) 4 (3): 247–261.
Published: 13 October 2020
... Attribution License 4.0 (CC BY-NC-ND) . condensates cytoskeleton intracellular organization phase separation The cellular cytoskeleton is a dynamic structure consisting of filaments that constantly exchange monomers with the cytoplasm by nucleation, polymerization and depolymerization...
Emerg Top Life Sci (2020) 4 (3): 293–305.
Published: 08 July 2020
... between R-DPRs and aberrations in liquid–liquid phase separation (LLPS). In this review, we showcase several potential mechanisms by which R-DPRs disrupt various phase-separated compartments to elicit deleterious neurodegeneration. We also discuss potential therapeutic strategies to counter R-DPR toxicity...
Emerg Top Life Sci (2020) 4 (3): 355–364.
Published: 23 June 2020
...M. Sankaranarayanan; Timothy T. Weil Drosophila eggs are highly polarised cells that use RNA–protein complexes to regulate storage and translational control of maternal RNAs. Ribonucleoprotein granules are a class of biological condensates that form predominantly by intracellular phase separation...
Emerg Top Life Sci (2020) 4 (3): 281–291.
Published: 27 April 2020
... recruited to super-enhancers create phase-separated condensates. Transcription initiates within or at the surface of these phase-separated droplets and the phosphorylation of Pol II, associated with transcription initiation and elongation, dissociates Pol II from these domains leading to engagement...