Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, is a human-adapted pathogen that does not productively infect other organisms. The ongoing relationship between N. gonorrhoeae and the human host is facilitated by the exchange of nutrient resources that allow for N. gonorrhoeae growth in the human genital tract. What N. gonorrhoeae ‘eats' and the pathways used to consume these nutrients have been a topic of investigation over the last 50 years. More recent investigations are uncovering the impact of N. gonorrhoeae metabolism on infection and inflammatory responses, the environmental influences driving N. gonorrhoeae metabolism, and the metabolic adaptations enabling antimicrobial resistance. This mini-review is an introduction to the field of N. gonorrhoeae central carbon metabolism in the context of pathogenesis. It summarizes the foundational work used to characterize N. gonorrhoeae central metabolic pathways and the effects of these pathways on disease outcomes, and highlights some of the most recent advances and themes under current investigation. This review ends with a brief description of the current outlook and technologies under development to increase understanding of how the pathogenic potential of N. gonorrhoeae is enabled by metabolic adaptation.
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February 2024
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The cover of this issue of Emerging Topics in Life Science features a schematic representation of the bacterial acetate metabolism pathways, at which acetyl-CoA (red) is a centralmetabolite. Read all about it in "Bacterial acetate metabolism and its influence on human epithelia" on pp 1-13.
Review Article|
May 05 2023
Dinner date: Neisseria gonorrhoeae central carbon metabolism and pathogenesis
Aimee D. Potter
;
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Box 800734, Charlottesville, VA 22908-0734, U.S.A.
Correspondence: Aimee D. Potter (ap6ap@virginia.edu)
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Alison K. Criss
Alison K. Criss
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Box 800734, Charlottesville, VA 22908-0734, U.S.A.
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Publisher: Portland Press Ltd
Received:
March 03 2023
Revision Received:
April 10 2023
Accepted:
April 14 2023
Online ISSN: 2397-8562
Print ISSN: 2397-8554
© 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology
2023
Emerg Top Life Sci (2024) 8 (1): 15–28.
Article history
Received:
March 03 2023
Revision Received:
April 10 2023
Accepted:
April 14 2023
Citation
Aimee D. Potter, Alison K. Criss; Dinner date: Neisseria gonorrhoeae central carbon metabolism and pathogenesis. Emerg Top Life Sci 22 February 2024; 8 (1): 15–28. doi: https://doi.org/10.1042/ETLS20220111
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