Injuries to the brain and spinal cord have major clinical consequences with high costs for healthcare systems. Neural cell transplantation therapies have significant translational potential to promote regeneration post-injury with clinical trials commencing for various pathologies. However, there are challenges associated with current clinical approaches used for systemic or direct delivery of transplant cells to neural tissue in regenerative applications. These include risks associated with surgical microinjection into neural tissue (e.g. haemorrhage, cell clumping) and high cell loss due to systemic clearance or with cell passage through fine gauge needles into densely packed neural tissue. This article presents lines of evidence supporting the concept that cell spray delivery technology can offer significant translational benefits for neural transplantation therapy, versus current cell delivery methods. Potential benefits include rapid/homogenous cell delivery, release over large surface areas, minimal invasiveness, compatibility with neurosurgical procedures in acute injury, no predictable clinical complications and the capacity to combine cell therapies with drug/biomolecule delivery. Accordingly, we consider that the development of cell spray delivery technology represents a key goal to develop advanced cell therapies for regenerative neurology.
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October 2021
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The cover of this issue of Emerging Topics in Life Sciences (volume 5, issue 4) features a fl owchart from Hulme et al. showing the sources and characteristics of multipotent mesenchymal stromal cells (MSCs). Read more about the Current Topics in Stem Cells and Regenerative Medicine in this special issue.
Perspective|
June 07 2021
Stem cell sprays for neurological injuries: a perspective
William Woods;
William Woods
1School of Medicine (Neural Tissue Engineering Keele Group), Faculty of Medicine and Health Sciences, David Weatherall Building, Keele University, Newcastle-Under-Lyme, Staffordshire ST55BG, U.K.
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Daisy Evans;
Daisy Evans
1School of Medicine (Neural Tissue Engineering Keele Group), Faculty of Medicine and Health Sciences, David Weatherall Building, Keele University, Newcastle-Under-Lyme, Staffordshire ST55BG, U.K.
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Aina Mogas Barcons;
Aina Mogas Barcons
1School of Medicine (Neural Tissue Engineering Keele Group), Faculty of Medicine and Health Sciences, David Weatherall Building, Keele University, Newcastle-Under-Lyme, Staffordshire ST55BG, U.K.
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Nikolaos Tzerakis;
Nikolaos Tzerakis
2Department of Neurosurgery, Royal Stoke University Hospital, Newcastle Road, Stoke-on-Trent ST4 6QG, U.K.
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Christopher Adams;
Christopher Adams
3School of Life Sciences (Neural Tissue Engineering Keele Group), Huxley Building, Keele University, Newcastle-Under-Lyme, Staffordshire ST55BG, U.K.
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Divya Maitreyi Chari
1School of Medicine (Neural Tissue Engineering Keele Group), Faculty of Medicine and Health Sciences, David Weatherall Building, Keele University, Newcastle-Under-Lyme, Staffordshire ST55BG, U.K.
Correspondence: Divya Maitreyi Chari (d.chari@keele.ac.uk)
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Publisher: Portland Press Ltd
Received:
February 11 2021
Revision Received:
May 11 2021
Accepted:
May 19 2021
Online ISSN: 2397-8562
Print ISSN: 2397-8554
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology
2021
Emerg Top Life Sci (2021) 5 (4): 519–522.
Article history
Received:
February 11 2021
Revision Received:
May 11 2021
Accepted:
May 19 2021
Citation
William Woods, Daisy Evans, Aina Mogas Barcons, Nikolaos Tzerakis, Christopher Adams, Divya Maitreyi Chari; Stem cell sprays for neurological injuries: a perspective. Emerg Top Life Sci 29 October 2021; 5 (4): 519–522. doi: https://doi.org/10.1042/ETLS20210113
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