AAV mediated gene therapy offers the potential for curative therapies for many fatal and debilitating diseases, however the translation of these concepts into licenced products is stymied by manufacturing challenges leading to very high costs and delayed commercialisation. This is an issue which vector developers need to address, specifically around productivities and vector purities including levels of empty non-functional capsids. To date vector developers have focused on the optimising of vector targeting and gene delivery, however there is an increasing need to recognise the issue of manufacturability of vectors, and to be able develop screening and assessment of novel vectors to ensure that in future innovations and development can be produced to the required quality and in the desired quantities and at an acceptable cost.
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November 2021
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This special issue of Emerging Topics in Life Sciences (volume 5, issue 5) brings together a collection of perspectives about innovative techniques and ideas from scientists working in the life sciences industry. The cover image is an illustration featured in the piece discussing by ImmTOR™ by Brunn and Kishimoto.
Perspective|
November 10 2021
Manufacturing of AAV vectors: translational challenges from development to industrialisation
Tony Hitchcock
Cobra Biologics, Charles River, Newcastle Under Lyme, U.K.
Correspondence: Tony Hitchcock (ton.hitchcock@crl.com)
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Publisher: Portland Press Ltd
Received:
July 07 2021
Revision Received:
September 29 2021
Accepted:
October 08 2021
Online ISSN: 2397-8562
Print ISSN: 2397-8554
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology
2021
Emerg Top Life Sci (2021) 5 (5): 725–728.
Article history
Received:
July 07 2021
Revision Received:
September 29 2021
Accepted:
October 08 2021
Citation
Tony Hitchcock; Manufacturing of AAV vectors: translational challenges from development to industrialisation. Emerg Top Life Sci 12 November 2021; 5 (5): 725–728. doi: https://doi.org/10.1042/ETLS20210179
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