Our hopes of using the power of the immune system to control tumours have been partially fulfilled with anti-PD1 antibodies and other checkpoint inhibitors and the use of engineered T cells targeting lineage-specific surface markers with chimeric antigen receptors. Can these successes be generalised? Therapeutic cancer vaccines aim to educate or re-educate the immune system to recognise tumour specific or tumour associated antigens. After many false dawns, some positive data for the effectiveness of such an approach is starting to emerge in advanced solid tumours, albeit as combination therapies with checkpoint inhibitors. But is the field targeting the right antigens? Interventions using the most effective vaccine platforms to target certain sets of antigens in patients with low disease burden might bring impressive long-term benefits to patients as single agents.
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November 2021
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This special issue of Emerging Topics in Life Sciences (volume 5, issue 5) brings together a collection of perspectives about innovative techniques and ideas from scientists working in the life sciences industry. The cover image is an illustration featured in the piece discussing by ImmTOR™ by Brunn and Kishimoto.
Perspective|
September 08 2021
Therapeutic cancer vaccines: reasons to believe
Jonathan D. Moore
Epitopea Ltd, Salisbury House, Station Rd, Cambridge CB1 2LA, U.K.
Correspondence: Jonathan D. Moore (jon.moore@adventLS.com)
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Publisher: Portland Press Ltd
Received:
June 17 2021
Revision Received:
August 23 2021
Accepted:
August 24 2021
Online ISSN: 2397-8562
Print ISSN: 2397-8554
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology
2021
Emerg Top Life Sci (2021) 5 (5): 591–595.
Article history
Received:
June 17 2021
Revision Received:
August 23 2021
Accepted:
August 24 2021
Citation
Jonathan D. Moore; Therapeutic cancer vaccines: reasons to believe. Emerg Top Life Sci 12 November 2021; 5 (5): 591–595. doi: https://doi.org/10.1042/ETLS20210205
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