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Keywords: vasoconstriction
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Articles
Clin Sci (Lond) (2022) 136 (11): 803–817.
Published: 30 May 2022
... channel in the neuronal development, but its potential roles in vascular Ca V 1.2 channels and vasoconstriction remain undefined. Here, we detect Rbfox1 is expressed in rat vascular smooth muscles. Moreover, the protein level of Rbfox1 is dramatically decreased in the hypertensive small arteries from...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2013) 124 (6): 413–422.
Published: 27 November 2012
... through both the α-adrenergic and RAAS (renin–angiotensin–aldosterone) pathways. Although the independent contribution of these two pathways to elevated vasoconstriction with age may be substantial, significant cross-talk exists that could produce potentiating effects. To examine this interaction, 14...
Articles
Clin Sci (Lond) (2012) 122 (12): 581–590.
Published: 05 March 2012
... (−38±8 μl) and HR [−18±5 b.p.m. (beats/min)] (all P <0.05). In 2ADX rats, β-FXIIa had no HR effect, but decreased SV (−89±9 μl) and MAP (−4±1 mmHg), and increased TPR by 66% (0.59±0.15 mmHg/ml per min) (all P <0.05). After infusion, adrenally intact rats exhibited persistent vasoconstriction (MAP...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2007) 113 (11): 427–434.
Published: 01 November 2007
... is found in the circulation and enhances vasoconstriction. Under conditions that may favour the formation of short Aβ oligomers, as opposed to more severe polymerization leading to Aβ fibrillogenesis, we investigated the influence of LDLs on the vasoactive actions of soluble Aβ. Thus the actions of Aβ40...
Articles
Clin Sci (Lond) (2007) 113 (11): 449–457.
Published: 01 November 2007
... decreased body mass, but decreased body mass alone cannot account for findings of peripheral vasoconstriction. In conclusion, the findings suggest that reduced body mass relates to increased plasma AngII. POTS patients were recruited from patients referred to the Hypotension Center for investigation...
Articles
Clin Sci (Lond) (2007) 113 (1): 15–23.
Published: 01 June 2007
... 2007 The Biochemical Society 2007 arterial remodelling entrenchment haemodynamic function hypertension shear stress vasoconstriction vascular tone Correspondence: Professor B. Lowell Langille at Toronto General Research Institute, University Health Network, Toronto, Ontario...
Articles
Clin Sci (Lond) (2007) 112 (6): 353–361.
Published: 12 February 2007
... vasoconstrictor response to this neural output. It is suggested that this may partly explain the observed lower incidence of cardiovascular events in women compared with men. autonomic nervous system gender muscle sympathetic nerve activity regional blood flow vasoconstriction Unpaired Student...
Articles
Clin Sci (Lond) (2006) 110 (2): 255–263.
Published: 17 January 2006
... with increased vasoconstriction related to decreased bioavailable NO (nitric oxide) have decreased blood volume. Ang II reduces bioavailable NO and is integral to the renin–Ang system. Thus, in the present study, we investigated the relationship between blood volume, Ang II, renin, aldosterone and peripheral...
Articles
Clin Sci (Lond) (2003) 104 (4): 329–340.
Published: 06 March 2003
... vasoconstriction venous resistance 329Clinical Science (2003) 104, 329 340 (Printed in Great Britain) Contrasting neurovascular findings in chronic orthostatic intolerance and neurocardiogenic syncope Julian M. STEWART* and Amy WELDON* *Department of Pediatrics, New York Medical College, Valhalla, NY 10595...
Articles
Clin Sci (Lond) (2003) 104 (2): 163–169.
Published: 17 January 2003
... the patients (4.62±1.99ml·100ml -1 ) and the controls (3.18±0.74ml·100ml -1 ). The vasoconstrictor response to limb lowering was present in the patients (47.7±9.0% decrease in skin red-cell flux), but was impaired as compared with the controls (80.7±3.4%) ( P <0.05). The impaired vasoconstriction during...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 194S–197S.
Published: 01 September 2002
...%. During this ischaemia, coronary vasodilatation to acetylcholine (0.003–0.1 µ g) and sodium nitroprusside (SNP; 1–10 µ g) was markedly reduced, and coronary vasoconstriction to ET-1 (0.01–0.3nmol) was attenuated. After 30min of reperfusion, coronary flow, mean arterial pressure and coronary vascular...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 13S–15S.
Published: 01 September 2002
.... In vascular rings from obese mice, contractility to acetylcholine was also evident in the aorta, and that in the carotid artery was increased compared with control mice. ET A receptor blockade by darusentan treatment of the obese mice prevented enhanced vasoconstriction to acetylcholine, resulting in mild...
Articles
Clin Sci (Lond) (2001) 100 (3): 311–318.
Published: 02 February 2001
... complications. Correspondence : Dr Patrick W. F. Hadoke (e-mail phadoke@srv0.med.ed.ac.uk ). 26 6 2000 26 10 2000 17 11 2000 The Biochemical Society and the Medical Research Society © 2001 2001 endothelium human resistance arteries Type I diabetes vasoconstriction...
Articles
Clin Sci (Lond) (2000) 98 (3): 277–282.
Published: 09 February 2000
... combined with the existing evidence that angiotensin II stimulates the release of 20-HETE, a CYP-450 metabolite of arachidonic acid, suggest that CYP-450-derived HETEs may be important mediators in angiotensin II-induced vasoconstriction. However, the development of more sensitive assays for the detection...
Articles
Clin Sci (Lond) (1999) 96 (6): 577–588.
Published: 04 May 1999
...Clare M. EDWARDS; Janice M. MARSHALL; M. PUGH In control subjects and in subjects with primary Raynaud's disease, sudden sound evokes the pattern of the alerting response, which includes cutaneous vasoconstriction and vasodilatation in forearm muscle. However, whereas this pattern of response...
Articles
Clin Sci (Lond) (1999) 96 (5): 507–512.
Published: 14 April 1999
... in the pathophysiology of EM. Correspondence : Dr Faisel Khan 5 10 1998 8 1 1999 15 1 1999 The Biochemical Society and the Medical Research Society © 1999 1999 erythromelalgia laser Doppler flowmetry skin sympathetic activity vasoconstriction 507Clinical Science (1999) 96, 507ñ512...
Articles
Clin Sci (Lond) (1999) 96 (3): 241–251.
Published: 01 March 1999
... heart failure vasoconstriction vasodilatation 241Clinical Science (1999) 96, 241 251 (Printed in Great Britain) Investigation of distal aortic compliance and vasodilator responsiveness in heart failure due to proximal aortic stenosis in the guinea pig Martyn P. KINGSBURY, Wenxin HUANG, Silvana...
Articles
Clin Sci (Lond) (1996) 91 (5): 627–631.
Published: 01 November 1996
... assigned treatments: (i) control (no drug), (ii) low-dose phentolamine, and (iii) high-dose phentolamine. On each day cold intravenous saline (4°C) was given until both vasoconstriction and shivering were triggered or a maximum fluid volume (40 ml/kg) was delivered. Core temperature, peripheral...
Articles
Clin Sci (Lond) (1991) 80 (1): 59–64.
Published: 01 January 1991
...Aws S. Saum 1. Reserpine (5 mg/kg intraperitoneally) produced gastric mucosal vasoconstriction and injury in all rats within 6 h (injury score 38.8 ± 2.1 mm 2 , mean ± SEM). Coeliac ganglionectomy or the β-adrenoceptor-blocking drug propranolol (5–15 mg/kg) did not influence these effects...
Articles
Clin Sci (Lond) (1990) 78 (1): 39–47.
Published: 01 January 1990
...Ahmad A. K. Hassan; G. Carter; J. E. Tooke 1. Postural vasoconstriction in the foot was examined in 15 women during the menstrual, follicular and luteal phases of the menstrual cycle, and in 13 age-matched men on two separate occasions, in a constant-temperature environment (22°C). 2. Skin blood...
Articles
Clin Sci (Lond) (1989) 77 (3): 245–252.
Published: 01 September 1989
..., a fall occurred after starvation. 3. Underfeeding for 7 days did not affect thermogenesis or the degree of vasoconstriction in the forearm or hand in response to cooling. 4. After 48 h starvation, the thermogenic response to cooling was abolished and blood flow in the forearm remained higher than...
Articles
Clin Sci (Lond) (1989) 76 (2): 143–149.
Published: 01 February 1989
...% oxygen and general anaesthesia causing alveolar collapse, with only partial compensation for impairment of gas exchange by compensatory local hypoxic vasoconstriction. 3. When prostacyclin was infused, pulmonary vascular resistance fell by 3.2 ± 1.8 units (mmHg litre −1 min m 2 ), and pulmonary blood...
Articles
Clin Sci (Lond) (1988) 75 (4): 379–387.
Published: 01 October 1988
...Ahmad A. K. Hassan; J. E. Tooke 1. The mechanism of postural vasoconstriction in the skin of the foot was examined in 102 healthy subjects by using laser Doppler flowmetry. 2. In 45 subjects, when one foot was lowered 50 cm below heart level and the other foot kept horizontal, blood flow...
Articles
Clin Sci (Lond) (1987) 72 (3): 283–287.
Published: 01 March 1987
...Eugene D. Robin; James Theodore; Conor M. Burke; Stephen N. Oesterle; Michael B. Fowler; Stuart W. Jamieson; John C. Baldwin; Adrian J. Morris; Sharon A. Hunt; Antonius Vankessel; Edward B. Stinson; Norman E. Shumway 1. The preservation of hypoxic pulmonary vasoconstriction (HPV) in the denervated...
Articles
Clin Sci (Lond) (1987) 72 (2): 251–254.
Published: 01 February 1987
... The Biochemical Society and the Medical Research Society 1970 α-adrenoceptor blood pressure catecholamines ethanol vasoconstriction Clinical Science (1987) 72 , 25 1-254 SHORT COMMUNICATION 251 Effects of ethanol ingestion on blood pressure reactivity G. EISENHOFER*, D. G. LAMBIE AND R. H. JOHNSON...
Articles
Clin Sci (Lond) (1985) 68 (4): 373–377.
Published: 01 April 1985
.... 31 8 1984 8 10 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 isolated perfused rat kidney natriuresis neuropeptide Y sympathetic neurons vasoconstriction Clinical Science (1985) 68, 373-377 373 Neuropeptide Y: a novel renal peptide...
Articles
Clin Sci (Lond) (1981) 61 (s7): 445s–448s.
Published: 01 December 1981
...F. W. Amann; P. Bolli; L. Hulthén; W. Kiowski; F. R. Bühler 1. α 1 -Adrenoceptor-mediated vasoconstriction was studied before and during propranolol therapy in eight normal renin essential hypertensive patients; four were known ‘responders’ and four, age-matched ‘non-responders’ to previous β...
Articles
Clin Sci (Lond) (1981) 61 (s7): 129s–139s.
Published: 01 December 1981
...C. I. Johnston; M. Newman; R. Woods © 1981 The Biochemical Society and the Medical Research Society 1981 antidiuretic hormone haemorrhage orthostasis vasoconstriction vasopressin CIinicalScience (1981) 61, 1 2 9 ~ 1 3 9 s 129s STATE OF THE ART REVIEW Role of vasopressin...
Articles
Clin Sci (Lond) (1981) 61 (3): 281–286.
Published: 01 September 1981
...M. G. Collis; J. R. Keddie 1. Angiotensin-converting enzyme inhibitors can attenuate reflex sympathetic vasoconstriction in vivo. We have investigated the effects of captopril (SQ 14 225) on adrenergic vasoconstrictor mechanisms in isolated, Krebs-Ringer solution perfused, rat mesenteric arteries...
Articles
Clin Sci (Lond) (1980) 59 (s6): 145s–148s.
Published: 01 December 1980
...H. Sušić; A. Nasjletti; K. U. Malik 1. Renal arterial injection of bolus doses of angiotensin II or noradrenaline, (0.06, 0.12 and 0.25 μg) caused renal vasoconstriction and decreased blood flow to the kidney in a dose-related manner in dogs anaesthetized by sodium pentobarbital. 2. The effect...
Articles
Clin Sci (Lond) (1979) 57 (s5): 345s–347s.
Published: 01 December 1979
...L. Tobian; Mary Pumper; Susan Johnson; J. Iwai 1. In Dahl S rats becoming hypertensive while on a diet of high NaCl content there appears to be a blood-borne humoral agent which produces vasoconstriction in a bioassay using the isolated hindquarters of rats. 2. This vasoconstrictor effect strongly...
Articles
Clin Sci (Lond) (1979) 57 (s5): 161s–163s.
Published: 01 December 1979
... renin secretion in response to isoprenaline. 3. Renal vasoconstriction was abolished and the response in renin secretion to isoprenaline was restored by α-adrenoreceptor blockade with phenoxybenzamine. 4. In contrast, when renal vasoconstriction was prevented by dihydrallazine, suppression of renin...